NBME 17 Dopamine β-hydroxylase (NBME Answers)

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submitted by ∗cassdawg(1780)

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Perhaps worth noting here is that Dopamine Beta-hydroxylase is a membrane-bound enzyme found in the vesicular membrane. This means that the conversion of Dopamine to Norepinephrine actually occurs within the synaptic vesicle. Norepinephrine is the only transmitter known to be synthesized within synaptic vesicles. This is mentioned in less detail in SketchyPharm 2.2 Indirect Sympathomimetics.

Also, per FA, this reaction requires Vitamin C as a cofactor!

+2/- baja_blast(219)