Not in First Aid, but Drs. Sattar and Goljaan emphasize this point
In B-cell neoplasms (lymphoma, MM), the ratio of immunoglobulins is thrown off. Kappa and lambda refer to the Ig light chain genotypes, and is normally 2-3:1 for kappa to lambda. Here, it's almost 16:1, and this is a huge sign that there is a monoclonal proliferation of one cell type.
The other answer choices could refer to polyclonal proliferations, but a (mono)clonal neoplasm would be reflected in the surface k:l ratio as well as the G6PD isoforms for androgen receptors.
submitted by โbingcentipede(356)
Not in First Aid, but Drs. Sattar and Goljaan emphasize this point
In B-cell neoplasms (lymphoma, MM), the ratio of immunoglobulins is thrown off. Kappa and lambda refer to the Ig light chain genotypes, and is normally 2-3:1 for kappa to lambda. Here, it's almost 16:1, and this is a huge sign that there is a monoclonal proliferation of one cell type.
The other answer choices could refer to polyclonal proliferations, but a (mono)clonal neoplasm would be reflected in the surface k:l ratio as well as the G6PD isoforms for androgen receptors.