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NBME 16 Answers

nbme16/Block 2/Question#18

An animal study is conducted to assess the effects ...

Mucus production and secretion: increased; Activity of airway cilia: decreased; Alveolar macrophage function: decreased

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Can anyone explain why macrophage activity would be decreased in this? I wanted to pick one that had both mucus secreting activity as being increased along with increased macrophage activity with concomitant decrease in ciliary activity but this wasn't an option so I went with all increased. Since it's well-established that macrophages cause damage in emphysema (especially in smokers due to constant irritation from the smoke), how is it possible that macrophage activity would go DOWN?

kard  Mucus hypersecretion --> Induce airflow limitation in COPD "potential risk factor for accelerated decline in lung function" Cigarette smoke impairs both the phagocytic and respiratory burst function of neutrophils! Macrophages-->activated by cigarette smoke extract to release inflammatory mediators COPD--> alveolar macrophages and neutrophils are defective in their antimicrobial functions. Macrophages from COPD patients--> show reduced phagocytic uptake of bacteria. "Streptococcus pneumoniae and nontypeable Haemophilus influenzae" I Hope This Helps... +