need help with your account or subscription? click here to email us (or see the contact page)
join telegramNEW! discord
jump to exam page:
search for anything ⋅ score predictor (โ€œpredict me!โ€)

Retired NBME 15 Answers

nbme15/Block 4/Question#40 (reveal difficulty score)
An 18-month-old boy with severe combined ...
Irradiated packed red blood cells ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags:

 Login (or register) to see more


 +6  upvote downvote
submitted by โˆ—cassdawg(1781)
get full access to all contentpick a username

From what I can tell, the gist of this question is that he has SCID and since the SCID child has basically no immune system (particularly because the lack of T-cell immunity) there is a higher chance of transfusion-associated graft versus host disease (TA-GVHD) so blood products have to be irradiated.

Here is a medscape reference with who requires irradiated RBCs due to increased risk of TA-GVHD for your perusing.

get full access to all contentpick a username
i_hate_it_here  Just curious, are you a student? Your answers are always much appreciated. +4



 +3  upvote downvote
submitted by โˆ—shieldmaiden(32)
get full access to all contentpick a username

Irradiated blood destroys all nucleated cells, like in this case, we wouldn't want him to have foreign lymphocytes because it would cause GVHD for sure

Washed Blood eliminates plasma proteins, which is beneficial for patients with IgA deficiency for example

get full access to all contentpick a username



Must-See Comments from nbme15

cassdawg on Deoxyhemoglobin is a better buffer of ...
andro on T-lymphocyte thymocytes localized to the ...
cassdawg on Burning
cassdawg on 1000
cassdawg on Left ventricular pressure increased, right ...
cassdawg on Pancreatic enzymes
cassdawg on Decreased smoking
cassdawg on Low blood solubility
cassdawg on Glutamine
cassdawg on Prolonged fecal excretion of the organism
cassdawg on The neural plate is present, but the neural ...
cassdawg on Immunohistochemistry
cassdawg on epp Amplitude: 1; mepp Amplitude: 1; ...
cassdawg on Action of pancreatic enzymes on adipose

search for anything NEW!