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NBME 15 Answers

nbme15/Block 1/Question#33 (9.9 difficulty score)
A 75-year-old woman is brought to the ...
Releases NF-κB after undergoing phosphorylation🔍
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 +5 
submitted by specialist_jello(12),

NFKB is in its inactive state bound to IKB. As a part of the classical pathway, bacterial antigens bind to TLR and activate IKB kinase, (kinase phosphorylates)

  • IKB is ubiquinated and degraded

  • NFKB enters nucleus and synthesises the inflammatory stuff

Uw QID: 11955