NFKB is in its inactive state bound to IKB. As a part of the classical pathway, bacterial antigens bind to TLR and activate IKB kinase, (kinase phosphorylates)
IKB is ubiquinated and degraded
NFKB enters nucleus and synthesises the inflammatory stuff
Uw QID: 11955
Here is a simplified image of the NF-kappaB pathway. NF-kB is important in transcription of inflammatory genes. A lot of PAMPs (pathogen associated molecular patterns) and inflammatory signals lead to activation of NF-kB which in turn mediates a whole heck of a lot of immune-related responses.