need help with your account or subscription? click here to email us (or see the contact page)
join telegramNEW! discord
jump to exam page:
search for anything ⋅ score predictor (โ€œpredict me!โ€)

Retired NBME 15 Answers

nbme15/Block 2/Question#26 (reveal difficulty score)
A 69-year-old man with benign prostatic ...
Bethanechol ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags:

 Login (or register) to see more


 -3  upvote downvote
submitted by โˆ—cassdawg(1781)
get full access to all contentpick a username

Bethanechol is a muscarinic cholinergic antagonist with no action on nicotinic ACh receptors. Bethanechol is commonly used to treat urinary retention by activating bladder smooth muscle via M3 Gq receptors that function by increasing phospholipase C conversion of PIP2 (phosphoinositide) to IP3 and DAG (FA2020 p240, p237, p238).

Wrong answers:

  • Atropine is a muscarinic antagonist which would non increase phosphoinositide turnover but decrease it (FA2020 p241)
  • Neostigmine is an indirect cholinergic agonist that works by inhibiting acetylcholinesterase that does work at the muscarinic synapse as well and is used for myasthenia gravis as well as postoperative ileus and urinary retention
  • Succinylcholine is a depolarizing muscarinic agonistnthat causes sustained depolarization and prevents contraction, used as a paralytic in anesthesia (FA2020 p551)
  • Trimethaphan is a drug that counteracts cholinergic transmission at the nicotinic receptors of the autonomic ganglia and therefore blocks both the sympathetic nervous system and the parasympathetic nervous system. It is used to treat hypertension
get full access to all contentpick a username
cheesetouch  FA2018 P236 +5
jmd2020  Bethanechol is a muscarinic AGONIST, not antagonist (other it would further exacerbate BPH) +7



Must-See Comments from nbme15

cassdawg on Deoxyhemoglobin is a better buffer of ...
andro on T-lymphocyte thymocytes localized to the ...
cassdawg on Burning
cassdawg on 1000
cassdawg on Left ventricular pressure increased, right ...
cassdawg on Pancreatic enzymes
cassdawg on Decreased smoking
cassdawg on Low blood solubility
cassdawg on Glutamine
cassdawg on Prolonged fecal excretion of the organism
cassdawg on The neural plate is present, but the neural ...
cassdawg on Immunohistochemistry
cassdawg on epp Amplitude: 1; mepp Amplitude: 1; ...
cassdawg on Action of pancreatic enzymes on adipose

search for anything NEW!