hTe ewvarneieL ukrB Potl si lamyni ditnprtreee by tsi X dna Y heirteet. snTpc nequitso seatst ahtt iignvg B6 iancsesre het tacitiyv ot raomnl esll,ve hhwci smane the ittaiycv uodlhs be eth asem as the ecna rn.emlH,o ihter Y renetctpi duhsol be het m,esa os we aer eebnewt oscceih B adn .C A dna D od nto haev teh msea Y eiptcnert as arihomnreH.lg nstcaitoncoern fo B6 aecsdu tycivati ot oecbme raln,mo dan so maVx liwl not be nnigachg nda we nac neclac A nad .A D sha a lrewo Vxma dna D hsa a mhuc hhigre .hmx VaTe dercfenfie etnbewe B adn C is ni hetir Km. vniogM to eth ftle no eth X isxa mksae the Km elwro adn sllet oyu htat ftnfyaii si ighrohes ouy lwdou ont ened meor 6B. tBu in uor aces ifitfnay fo teh nyzeme rof 6B si lelyar o,lw iwhhc si why we need a tno mreo 6.B
nI m,asmruy ew twan teh asem Vamx adn a hgeihr Kme.W natw hte oln"m"ar vitaytci asme( amvx as anro)lm and we ndee hgihre ontasum of 6B rfo cescuss to nafyisif of the yeemnz orf 6B is laorbbyp vyre lwo.
iceohC B has a /)Km(1- veula oescrl ot 0 hhiwc mesan mK is rlweo adn itafifyn fo eth zmyeen orf tis truaebtss is epsru w .oshliT ksmea seens sa giivgn hhrgei smatoun of eht ti"ipmec"otve tsaesubtr 6B is gphnlei.
iNndege irgeh"h tntcnasr"ooncei fo teh 6B rfo zynmee vtactyii is noterha yaw of inaysg Km si ihghre ceisn meor is qeudirer orf 1/2 axvm ytvitci.a acserIdne Km ealvsu eulsrt ni Km/1 gienb selarml colser( to 0 on teh )sx,xi-a chihw is mrddaoneetst in sneraw cceohi .B
A rlan""om menyez tatvciiy ni the nsereecp fo hegirh B6 tetarcionnonsc smnea thta maxV is nto ig,hgnnca btu Km i.s
meoS fo sehte iotsanpxlane reylal dgoin teh osmt. If eth emzyen is eabl ot rseanice to larmon titviayc thwi a hihreg eellv fo the rt,aestusb thta mnase ee’wr in a oiitemctepv hibiirton iotia.ntsu Coeeiimtvpt sawayl cssoers no het aghr,p os ew cna lmntieeia A nda D.
oNw ew yeaanlz .mK eW nawt mlsla Ksm’ orf entotp .esynezm Siez does otn aaylws mttear .😉 pxcEet ni tish scae we dtn’o ntaw ttha tcny,peo ew wtna ot kool for a el(y/arl1 gib )mK, v(alue htat si olrsec ot ez,o)r cb ew twan a weak gib mK to eb ealb ot peoworerv teh tvmeecitopi hont.iriib oanpmrigC the iraeinmng 2 s,coiehc B hsa a Km ulave csloer ot orez so e’esthr oury nrsa.ew
For hsti onutiq,se I asw hkgniitn htta tehy kedsa uoy mreoacp ot a omnr“a”l pr,nose so the xmVa dtwu’lon hcagen scein etyh tesat taht sih atityivc ruensrt ot a lnamor vlee.l lOyn hte xxsai- uldwo neisc ti uodlw be at dnesriaec octnconrneisat in pnrosiamc.o
oS i dnouf shti estinoqu ucuidl.s.oi.r teh anpnxtaielso rddipevo ddi ont llaeyr relac ti up rof m,e tub i kntih i tuesdnndar it now lasepe( rotecrc em if m'i )rgw.no
Ftsri and seofmo,rt Im' otn vnee urse fi hist is rytul a avrerenkeeubiw-l ,lpot insce teh x-Xias si ton /K1.m
uB,t omer ,elrgelyan I teird to nudtaernsd htaw eeadphnp at hobt mretexes of P]PL[ nda ltecioy.V
Ak: PsLP :ruesloyf rewhe no teh aprgh is ]PP[L ?ghhteis lleW, if eht X-isxa si aqule ot ,P/P1L LPP uoldw be ta tis tsiehhg ta teh alveu sctlsoe to 0 no teh xsi-.ax ihnt:k( ahwt is 1 idedvdi by a inbo?lli RVYE LESCO OT ZORE). hTsi oulwd osdoepnrrc ot a point lgoan teh sixy-a for eth ezsnmye iycavti.t In oehtr wo,dsr PPL is at tsi etishgh taioccnnenort at the hagrsp tirt.enYpec-
emmeRrbe hwta ew alos ai:ds ewnh het medtuat nzemey is urndao slto of PP,L ti ibsyalcal uoincntsf klei a nml zn.eeym ishT eanms, hatt the xamV of teh uedtamt neyemz is ueeatnliqv to the xaVm of eth aorlmn ye.menz erfoTrhee, hTe V/1xam of hbto ynezmes era iet..e.ualvqn ta teh hcieTrpsni-t!yte si !igb If uoy egt tshi f,ra tenh oyu cna melinaite )A( nda )(D, ecsni heets phagsr vhae ienetdffr e-rpisYtcetn dierf(tfne V-ms)xae fro rhtei reeiptecsv .syezmen
oMgivn ...on
lceoiVyt :)(V nWh e V si at its ghsheit .e.i( a)xV,m the ualev of /V1 ulowd be at tsi lw.seto g(naA:i tnkhi of ti ltry:ilpaacc hatw is 1 ddeviid yb 1 l?ilbino )~!0 f,rereoThe teh eluva fo 1V/ is at tis weltso enhw eht a-xysi si queal to 0. eeerTf,hro The amVx of tsih rusocc ehnw eht x-aisy si lsceo to z.eo.r. eserH eth tghni ..hot stehe eesynmz uereiqr tfeerifdn lslvee of LPP to eoepatr ta a-Vmx. Re,rbmmee the mVxa- fo hte EDUAMTT zemney wlli ehappn ta a umch HHIEGR PLP][. rO eey,vrcsonl teh xVam- of eht LNOARM myneez llwi paehpn at a chmu WROEL [P]L...P
eb aeawr atht het xasix- fro siht ioetnqsu is otn Km"" tB(v6i si not het es rthsttu'aabt ]i.1Vt[B6/ ot miiysf,p abcusee the maxV si naogn saty hte ems,a uyo juts ndee to seiecran Bv[ti]6 ot gte het msae aVmx (aka htsif to htgir on het isa-xx). nt D'o be ofeodl ardnou yb hte oneuqsit .werirt
ybdNoo sha wndseera hist uiteonqs uhhgtor eth elns of a nngrelia ebotcivej teuqi eyt so s'eerh ym 2 ct:nse Km is SDEEANRCI cb thsi itnteap hsa an zmeney thwi an eovlarl REOLW atfnyfii ac(n eb coceretrd ot olramn raetf an ceireans ni ss)ubtaert chihw is tarchcecsritia fo TEIEOMCVPTI ihn,iotbnii iwhch si hyw the lnei fo the .pt is one fo etvmtpicieo tiibniionh no a LB lpot
heT tosuqine si lcaialybs netgsit up a uotiaitsn irlaims ot thta fo a ivcometptei .boitrihin Teyh asy atht gerhhi tceiotnncasorn of dylxpiaor pheosathp nicrasees het iitatcyv of the zeynem ot mornla lseel.v irlamliyS, nhwe uyo vaeh a vitetpimeco initohrib nda cniserae hte caiernotnocnt of sbtrut,eas eth nzeemy acn eacehvi the emas axmV as if oithwtu hte nrihtii.ob
mbermeeR 1) etmitvipeco robstiihni ~ esnil Csors ta er t-t)ens2iyc iovenpe-Ntotimc bhsniitoir ~ on leni orscs
gnoL wanser a,ehda ubt earb iwht em.
:HITN v lsook nkid of lkei y, heaewrs k slkoo reom ielk x.
etytrn-ceip = xa/1Vm
in-eprtxetc = mK/1
etoN ttah amVx, sa a mesaeru fo cemrpaerfno, cna be redltea hthorgu nyma histg.n wiael,nhMe Km is a tse hiraccrstteica fo the y,ezenm adn ontacn be rlt.edae
nI hsti ,peaxlme the eyenzm remfcrepnoa aVxm)( is rcesdneai yb isgneinrca teh imnavit rccotofa os taht it earcshe a lmr"no"a tvtcai.iy w,vreeHo eth nyzmee si tlsil yretlnihne ttyish deu to a naintoegcl ,edectf so hte mK satys teh s.ame
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