ehT vneLraewei ukrB lPot is mlynia dertrnitpee by tis X nad Y Ttrpts eeehc.in qesotiun ttssae that iiggvn B6 raessncei hte itcivyta to ornmla sleevl, hiwch seanm the ytviiact hdsoul eb eth emsa as teh el ,.anceHmorn theri Y eteticrnp dhsoul eb eth sa,em so we are eetwben eccohsi B and .C A dna D od ont evah hte easm Y cttprenie as h nlHgimrroe.a cntaonsntoceri of B6 ecsuad yitticav to mboeec lm,aorn adn so axVm wlil not eb acgighnn nad ew can lcneca A nda DA . sah a ewrol maVx dan D ahs a hcmu gihrhe VThx.ame idffreeenc wbteeen B dna C si ni rhiet .Km oMigvn ot eth etlf on eht X isxa skame hte mK lorwe and letls yuo ttah iitfnayf si g ihoserh oyu ulodw otn nede roem B.6 tuB in ruo acse iyfnatfi of eth eznemy for B6 is yalerl l,wo hihcw is ywh we eden a otn orme B.6
In ymar,mus ew awtn hte aems Vxam dan a ihrheg .em WK atwn the "lrmaon" ctvyiait asm(e maxv as lnam)or and we dnee geihhr tsmonau fo 6B fro cuscses osiy ifnfta fo teh emznye fro B6 is baybplro yrve ol.w
ecoChi B sah a 1/(K-m) vueal rsecol ot 0 wihch esman mK si erolw adn tfynifai fo teh zmenye ofr tis turbatess is ersup hlowT.s i smkea ssnee as ggiivn grheih atmonsu fo teh ioci""vetemtp btastuser 6B si nglihp.e
eNiengd "ihhreg cntniseoatrco"n fo teh B6 ofr eynezm tyaiivct is hortane awy fo gnsaiy Km is herihg nseci oerm is uredireq ofr 12/ xvam yvcitiat. recdsnIae mK ueavls rtusel ni 1/Km gibne rasellm (rceslo ot 0 no hte ,ax-i)sx cwhih is tdesdetrmona ni aswenr iochce B.
A nomra"l" nymzee vcitiaty in eht cnepeers of rghieh B6 iocaenrotntscn nmeas ahtt axVm si nto cagnhngi, tub Km s.i
emSo of ehste inpsoetnlaax ralyle oidgn hte mst.o If teh eznmey si aleb to ienrseca to rnoaml cayvttii with a eghirh lelve of teh bssutaet,r ttha nasme rewe’ in a ettivpcomie iiroitnbh tstain.uio Citmptveeio awsayl csesosr no teh agrh,p so ew cna iaelmetni A and D.
wNo we yanleza K.m eW want sllam mK’s rof teontp mynesez. eziS oesd not ywaasl mettra .😉 xcEpte in tish scae ew dt’no nawt htta e,ctpyno ew want to loko fro a y(/1ralel bgi )Km, lavu(e ahtt is secolr to eo,)zr bc ew ntaw a weka big mK ot eb eabl to vreowrpeo het teicoitemvp tino.biirh agorpimnC teh narieingm 2 ch,icsoe B ash a mK uavel solrce to rzeo os ’setehr ryuo ernasw.
For tshi estiqn,ou I aws ihtngink thta yhet daske yuo rmapceo to a “onrlam” ,nsrepo os the xaVm t’luwdno naehgc inecs hyte atets htta ish tviactiy tsreunr to a orlmna vee.ll nOly eht xiaxs- oludw ecsni it uowld eb at ncaesderi tenonctsncaior in sarn.pcioom
So i dounf ihts istueqon uorl..si.dciu teh xnaalnotsipe reoidvdp ddi ton elraly crlea it up ofr ,em tbu i htkin i satdrunend ti wno epsla(e roctrec me fi i'm orwg).n
Ftsir adn or,omefts 'mI otn vene eurs fi shti is urytl a berevuln-eiwreak ltpo, isnce teh ixa-Xs is otn m./1K
t,Bu roem e,lnaglery I rtide to sdnenuardt twha dhnpeape at tboh xeemtsre of []PPL nad yteViol.c
PLsA :Pk loyre:sfu weehr on teh arhgp si [P]PL ihtgh?se l,eWl fi het Xxisa- si aluqe ot P,PL/1 LPP wludo eb at ist gsehhit at eht ualve lcssote to 0 on the xis-.xa (htkin: thaw si 1 idvdied yb a ?iblonli VERY COELS OT .E)OZR Tsih lodwu sepoornrcd to a otinp aolgn het as-xyi orf teh eynzmse i.ytivatc In ohtre ,dwrso LPP si ta tis ithhesg tntnaencoirco ta the rhaspg Y-perttnc.ei
rRemmbee hatw we losa is:da nwhe eht uteatmd enymez si dnaoru tslo fo ,PPL ti bayclisla ocfnstuni lkei a mln ezy.emn shiT ,aensm atth eth mxVa fo eht etatdum eeynzm si lqvaueinte to het Vmxa of teh larmno z.enmey ferTrehe,o eTh 1mV/ax of thbo smezeny ear ieu..lqnvtae. ta het ietes!rhTipncty - is i!gb If oyu gte sith raf, hten yuo acn lemaitien ()A and )(,D eincs esteh gspahr eavh nedriftef ne-tiscrYpet ri(dffeten a)emVs-x fro rhiet sceetevpir yenmsze.
oiMngv .n..o
itlceoVy :)V( nh eW V si ta sti gistehh ..(ie x)a,Vm eth elvua of V/1 wodul eb at tsi tsolw.e nai:(gA ntikh fo ti caiatllr:pcy tahw is 1 iddevid by 1 nil?ilbo ~!0) hreeTef,or het evual of 1V/ si at sti wotesl enwh hte sy-aix is eaqul to 0. hfore,Tere The Vxam of hsti uorcsc nhew eht -asxiy si oelsc ot .r.z.eo esHer het inght th.o. heest ezmysen qeuierr tdfeenirf vlseel fo LPP to aerpoet at -.maxV ,emrRebme eht Vx-am fo the EDTUAMT enmyez wlil pnepha ta a umch EHRIHG ]LP.[P Or vrese,nclyo the -xmVa of teh NOMRAL nymzee will npphea ta a umhc LORWE ..PL.P[]
eb reawa ttah teh ai-xsx ofr sthi sintuoeq is nto ""mK (tv6iB si otn het aarstttb'sut eh .t[16B]/iV to yf,mspii csubaee eht xmaV is anogn tasy teh ms,ae oyu sjut eedn to rsecaein i6]Btv[ ot get eht easm Vaxm kaa( tsihf ot rhitg no teh -xs.)ixa Dtn' o eb lfdeoo duoarn yb teh onseiuqt itr.erw
obdNyo sha saerdenw htis nouqstie ougtrhh eht nlse fo a gnilraen eotvbcije eqiut ety os ehrse' my 2 cns:te Km is NDREEACSI cb sith atnipte sha na zenmey iwht an olravel WELRO nitfifay ac(n be ccretoerd ot omrlan refat an caeisnre ni uertstabs) icwhh si accsrhtrieitca fo PVITECMIOET tihni,iniob hiwch si wyh eth lnei of het .pt si eno fo ittmecpoive inboiiinth no a LB plto
eTh euqisotn is lscyaalib ntetgsi pu a ttianisou sriimal to atht fo a imteeipcovt rn.ohtibii eTyh asy ahtt ierhhg ittsoarnncecno of xprldyaio hpotahspe sresciane hte aitvycit fo eth eymnze ot lmrnao ellse.v iiSl,rmlay enwh uoy heav a tepveimitoc ihitobirn dna ceraisen hte rnanenocttcoi fo t,etuasrsb hte eymenz can ieacvhe het meas axmV as if htiwuot het iibo.rithn
rbeRemme )1 tpoeecimvti ionsbitihr ~ nilse ssCor at ty t)isn2-rece viiNnet-omocetp bhitisionr ~ on leni csors
gLon nweasr ,edaah tbu bear htwi m.e
INTH: v sloko indk of leki ,y rehwaes k kolos rmeo keil x.
ertty-ecipn = x/amV1
trec-peintx = 1/Km
Nteo tath xam,V as a eearums of nra,fpecmeor acn be eladert gurthoh yamn nhsit.g eha,inelMw Km si a tes iehatcrtsccari of eth zyem,en adn tcnnao eb dratlee.
In siht xpeamle, eth ynemez pnoeerafcrm m(xVa) si ndecirase yb csinranegi hte imtivna tcrcoaof so hatt ti acerseh a nma"rlo" tiivaytc. eveorHw, the enmezy si sllti elryhntine htsyit ued ot a ocitlngnae eef,tdc os eth Km assty teh a.sme
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