ehT eieenawvrL Brku tlPo si ynmial ptdrrietnee by sti X nad Y e npsTrtt.ihcee eisqotun ststae that gvngii B6 easnricse teh cavtiity to amrlon v,eelsl icwhh msaen hte vaycitit lhsuod eb teh seam as hte eamro.nn,eHc l hrtie Y tripecnet luhsod eb het me,sa so we ear ebewent ccohise B nad .C A and D do ton veha eth mase Y etertnipc sa .glaoihHr rnem recianotoscnnt fo 6B sdueca iycvaitt ot omcbee ao,nlmr nad os mVxa lwli nto eb gncighan dna ew acn enccla A and D .A hsa a lowre Vmax and D sha a mcuh hrhgei haxTVem. dieecrnffe tnweebe B dan C si in hrtie m.K gonivM to hte lfte on het X sxai kaesm the Km elorw adn setll uoy thta tiynaffi is r ioehghs oyu lduow otn dnee rmeo .B6 tuB ni oru sace iantfyfi fo het eneymz rof B6 is lleyra ,olw ihwhc is yhw we eedn a otn meor 6.B
In umayr,ms ew twan het same aVmx and a ihhreg eW .mK wtan eth m"o"rlna tyavctii (aems vmax sa nl)amro nda we ndee geihhr onstaum fo B6 for scscuse tyonfi iafs fo eht emyezn fro 6B is rbpyolba yevr lw.o
oechCi B ahs a m(-)1/K avelu slceor ot 0 hihcw nsema Km is orewl dna iftnfayi fo hte zenmye orf ist rstsuetba is prseu iwosh lT. aksme eness as vinggi ghreih nsotmau fo het vcp"eimie"tto taeutbsrs B6 si nilh.gpe
neideNg ehrihg" cntt"nonrosecia fo the B6 orf eznemy tictvayi si thranoe yaw fo syinag mK si ihrheg nesic roem is rqdrieue rfo 2/1 xmav yitcivt.a scIrendae mK eaulvs lurtse in K1m/ igenb asmlelr lroecs( ot 0 on teh x),x-ais wcihh si omsdedtnerta ni aesrnw oihcec B.
A ao"n"rml yeznem caiiyvtt ni eth rnpeeecs fo rhghie 6B scoionettrcann sneam ttha axmV si otn ncgiagn,h btu mK si.
meSo fo eeths pnseatalxoin lyelra iodgn hte tsmo. If eth eemynz si beal ot erniaecs to lnmrao cyattvii htwi a rhhgie elevl of teh tbtassre,u that naems rwe’e ni a mvpettoecii briiohtin .ntsuitaoi Ctmeivteipo yalswa cssseor on hte h,rgpa so ew nca teinmelai A nda .D
wNo we nyzaeal K.m eW awnt lmlas sm’K rfo etoptn zeseny.m eSiz eods ton yalwas ettram .😉 txceEp ni htis seac we do’nt ntwa atth ,npecoty ew want to oklo rfo a 1(eylalr/ ibg mK,) l(veua taht is scroel to oze,)r cb we nwat a ekaw big Km to eb beal ot oovrpweer hte tipovceimet thiiirob.n gpoarnmiC het gimrnneia 2 ,eccihos B sha a mK euavl rolesc ot eroz so eths’re uoyr serawn.
Fro htsi uneoqtis, I saw intknigh atth tyeh kades uoy oamcrpe ot a ”m“rlnoa prens,o os eth Vaxm duwlt’no gncaeh sicen yhte tatse thta ish iicvytta nrurest ot a rnoaml l.evel Onyl eht a-xsxi duwlo sneci ti doluw eb ta ianedersc ecsraoinontctn ni oarspcoi.mn
oS i fndou isth uiqnotse uird.ouic.l.s teh stanaxilenpo ipedovdr did ton ayrlel alerc it up rfo e,m utb i htkin i nsunedatrd ti won laspe(e corerct me if 'mi ro)ng.w
sritF nad eoomtsrf, m'I nto enve esru fi shti is lrytu a uberler-ieewvnak l,pto isnce eth s-xaiX is otn m./K1
,utB meor yngr,eeall I irtde ot raddsnuten wtah deaehnpp at hbto mxersete fo [LP]P nad tlo.yciVe
PLPA:s k rsloy:uef erhew on eth gpahr is L[]PP sihg?hte llW,e fi eht i-xXas si leaqu to P,1L/P PLP wulod eb ta sit hhsetgi at hte alvue elsotsc ot 0 on het saixx-. i(t:hkn wtha si 1 iddvdie yb a oinli?lb EVYR OCSLE OT OEZ).R hTis ludwo ordseconpr to a notpi gaoln hte asiy-x fro hte smenzye tiva.cyit nI treho dr,wso LPP is at tsi heghtis ionotnaecnrtc at hte gphasr rnteYc.i-ept
emrbReme hawt we aslo aids: whne the dumtaet zemyne is odnuar otsl fo ,PLP ti cslaliyab tcnnfisou lkie a lnm nez.eym sTih emas,n hatt the mVax fo the etmuadt zmynee si uaqeieltnv to eht Vxam of eth anmorl n.mzyee rreefh,Teo The xam/V1 fo hotb esyeznm era .qnta.ueliev. ta hte nTi eshcrpt-!iyte is i!bg If uyo etg htis ,far hnet uyo nca aminieetl A)( and (,D) sinec ehets pshrag eahv ifefntred pceensYirt-t etfri(fnde -asm)eVx rfo ihtre iveesrepct z.msnyee
Mngvoi ..o.n
Vitylcoe (:)V hne W V is ta sti tehihsg ..i(e )xVa,m eth veual of /1V dwolu eb at tis losetw. Agi:an( ihtnk fo it yarltpialcc: twah si 1 eddviid yb 1 ilni?olb 0~)! oe,reeTfrh eht uvael fo 1/V si ta ist lwesto ewnh teh syxai- is qeual ot .0 ohrf,eereT The xmVa of sith sucocr wneh eth yix-as is secol to ..oezr. erseH teh hignt hot.. hsete ezeysnm ueeqirr tfnredfei llesev of PLP ot eeptora ta V-x.am eebm,emRr teh V-amx of eth TUATEMD zeyemn ilwl ephpan at a uchm GRHEIH PL[.P] rO rncvl,oysee hte ma-xV of the MORNLA nmezey wlil npahep ta a chum REWLO LP.[P..]
be arewa tath eht xsxi-a fro isth uoiesntq si tno ""mK 6tiv(B si ont hte burttesa ha'stt [tV]B/6.1i ot sp,mfyii eaucseb teh Vxma is ngaon asyt hte mesa, uyo sutj need ot rcesanie vt]B6i[ ot egt eth esma axmV ka(a itfsh to gtirh on eht xs-)ixa. 'no Dt eb fodoel rdnuao by eht oqtiesnu wiret.r
ydobNo hsa srwdeean stih etonsuiq hougrth eth nlse fo a laierngn ctejbivoe quiet tey os re'ehs ym 2 n:ctes mK is RCEESDAIN bc hsit pneaitt has an nmzeye htwi an lvorael OWLRE itayffni na(c be coerctdre to lmoanr teraf na saecnrie ni s)surtteba whhci si ritthiecacrasc fo IEVTCPOIMET ibtnion,hii ihwhc is hwy eht neli of het tp. is oen of tvmoiecetip iniitniohb on a BL tlop
heT oiutesqn si saalibylc tngeist up a aotuntiis simrali to htta fo a timtveopeci tibior.inh eyTh sya ttah ghhrie nintrscooacnet fo dalxpyior ahspehopt ernesiasc the tvcayiti of teh nzeyme to alnorm .eleslv ,mSilryila wenh you heva a otiemvptcei iinbrioth nad iaecsren teh ocennrnottcai fo ,trteassbu teh enmzye acn eicahev the mesa Vxma sa if wiuhtot the rbtiii.noh
mbrmeRee ) 1 emotpectivi rtsobiinhi ~ eslni oCrss at r-tteiec)sy2n itpvmNotneo-eic rbnistoiih ~ no lnie srosc
oLgn asnrwe aaehd, btu rbae thiw em.
ITHN: v slkoo kidn of like ,y srheewa k soolk omer kile .x
rtypncet-ei = x/1Vam
ip-cxtreent = m/K1
eNot ttah ,Vmxa as a ermaeus fo errnpeof,mac can eb taeelrd rgtuohh nyam gnith.s whaM,ieeln mK si a ets iaiearchrsctct fo eth yeemz,n dan anctno eb .laeretd
In ihst eemlxa,p eth zyenme fmerepcrano V(x)am is reesniacd by einacnrigs eth vtinmai facrocot so atth ti ehcsrea a lnro"m"a ya.ivttci eoHrwv,e eth ynemze si slilt nhiretlyne tstihy due ot a nitcoenalg te,ecfd so the Km syast het esm.a
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