heT eeirLvnaew kuBr lPot si imanyl peritdteern by sti X nad Y eeT.henitpr tsc tqeiunso asetst atht gngiiv 6B rscieneas teh ivactity ot nlramo evll,se hwhci nmsae the ttvayiic dhouls be teh asem sa teh Hneon,aec l.rm rteih Y pertnciet sluodh be hte ,msae so ew rea bentewe hcoceis B adn .C A and D od nto veha eht emas Y tnpciteer as aireonlm H.grh ocatnentroisnc of B6 secuda atyiivct ot mcbeeo a,nmrlo adn os amxV wlli ont eb inagcnhg and ew cna nalcce A dan D. A sha a rwoel mVax adn D ahs a uchm igrhhe m. ThVxae fdnfeceire wnebete B nda C is in ehtir K.m igovMn ot eth eltf no eht X iaxs skmea het mK lrowe adn lelts oyu tath yifnfita is sh ihrgeo oyu wludo tno eend mero B.6 tuB in ruo sace iiyftfna of teh nyezme for 6B si areyll w,lo cihwh is yhw we eden a ont orem .B6
In srym,uam we tnaw hte emsa xaVm nda a irhghe Wme.K tawn eht aoml"nr" tivyiact aes(m mvxa as ml)nrao dna we deen rehihg usmatno fo B6 rfo scscues noyafitifs fo teh nemzye rof 6B si obbalpyr vrey low.
Coihce B sah a (-K/m1) leuav lrsceo to 0 hchwi esamn mK si wreol dna fyiifnta fo het zyneem orf ist retautssb is rsepu ilTh. wos mseka nesse as ggnvii iehghr somutna fo eth c"ipvt"eimeot asbtutser 6B si leginh.p
egeiNdn ihrghe" tcaoinen"rotsnc of het 6B ofr ymneze ivcaiytt si enthoar ayw of nysgai Km si girhhe ecsin more si edrqueri for 21/ vmax tvci.atiy drsaenIec mK usvael lrsute in 1mK/ ibnge rlmlsea (rscleo ot 0 on het s)ixx-,a hihwc is tseertmoandd ni swrane hoccie B.
A ola"rnm" nezmye atciyivt ni teh eercspen of hhergi B6 tncnrcesnoaito sanme hatt Vamx is otn h,nagicng but Km si.
mSeo of etesh alixoepntans alelyr ongdi teh tom.s If het ymezne is abel to nceirsea to ronalm iytticav wiht a ghhire velel fo eht retua,ssbt tath emsan weer’ in a cottiimvpee rhitoinbi tiso.intau Cimtoveepti ywasal csesors on the hp,agr so we acn iaetenlim A and .D
Now we aeylnaz m.K We natw slmla K’ms for ptntoe .nseyzme Sezi odes otn aalysw rtaemt 😉. ctpeEx ni stih scae ew o’dtn nwat atth poc,neyt ew ntwa to lkoo rof a ey/r1lal( gbi ,m)K (uaelv htta si rocels ot e),zro bc we tawn a kewa big Km to be ealb ot wrropeoev het tticieeomvp ibhon.tiri nigmprCao eht naeiimgnr 2 hi,eocsc B hsa a Km uaelv crleos ot zroe so he’rets rouy reawsn.
orF htis ,tnqseoui I asw nkitnghi htta eyth aeksd yuo ercopam to a oam“l”nr esnpr,o so eth Vxam ndoluw’t aghnec insce yeth tsaet hatt shi ititacyv rusnrte ot a oanlmr e.lvle Only het i-xxsa dwlou icens ti dwulo be ta ieedrcnas rscatenonotnci in pno.sacmoir
So i fudno thsi otqusnei isd..uulc.iro eht onpstalanixe rpdevoid did tno lalyer alrec ti up for ,me tub i ntkhi i tnduernads it onw slp(aee oerctrc em fi 'im gwn)ro.
tiFrs nad rmofes,ot 'mI otn neev ruse fi iths si rltuy a iwanekel-reebrvu ,lotp eiscn het axis-X is otn /K.m1
,Btu rmeo arely,ngel I etird to rtdnundesa twha enhpapde ta hbot etesermx of [L]PP nad leVo.ytci
P sLAkP: :urfysleo erwhe no het hprga si P][LP egish?ht ,elWl fi teh s-Xaix is eaqul ot P,/1LP PLP wdlou eb at its shegthi ta teh leavu sescolt to 0 on eth x.xia-s (t:nhik thwa si 1 diddvei yb a inibllo? YERV CEOLS TO ZRE).O hsTi owdlu nspdeocror ot a oinpt alogn teh yisx-a rfo teh eznemsy cyii.avtt In horet s,drow PLP is ta tis hgthise oectinnonratc at eht rpsahg e.enYcrpitt-
bmeeemRr hatw we oals dasi: nhew het udttmea emynze is unraod tsol fo PPL, ti lscblaaiy nctfiunos ekli a lnm yeen.zm hTsi s,mena tath het Vamx fo eth uamttde ynzeme si etinuveqla ot teh Vmxa of the aronml yn.ezem ererohTfe, hTe amV/x1 fo ohtb smeeynz rea .qliun.vetae. at eht esrictyhepTi- n!t is bgi! If yuo tge htsi ,afr then oyu anc litneaemi A)( dan D),( nsice etehs hgsrpa heva ediffnrte estpir-cteYn dere(iftnf xe)a-mVs ofr erhti vpsceeerti zyesnem.
ovigMn ...no
eyVtiloc :()V When V si ta tsi gtehsih .e.i( a,mxV) the laevu fo /1V odlwu eb at sti wtlse.o aig(:An intkh of ti clcaiatrpyl: hatw is 1 dvdedii yb 1 ?lbiinlo )!~0 frheo,eerT teh uaelv of /V1 si ta sit ewslot enhw het siy-ax si lquea ot 0. oreref,eTh heT Vaxm fo itsh sorcuc ehnw teh ayxis- is eclos ot ..rz.eo erHes het gntih t..ho seeht ysmeezn irereuq fdfetnire elselv of LPP to aeerpto ta .x-Vma Rr,ebmmee het a-Vmx of eth MTTEDAU nmezye llwi panpeh at a uhcm HEGIHR L]PP.[ rO o,nvryclese eht xV-ma of the MORANL mzeney iwll peahpn ta a ucmh REWLO .[L].P.P
eb aearw thta eht x-sixa rof isht qteoiusn si otn mK"" i(tBv6 is ton eth tus atbtehra'ts t]61[BV.i/ to fi,isypm sbeacue the axmV si angno sayt the s,eam uyo ujts deen ot seeniacr i6]Bt[v ot egt eht smea aVxm ak(a shitf to ighrt no eht -sxxai.) otn D' be oldfoe uanrdo by eht onquesti iwt.rer
Nybood hsa sawdeenr hsit qoetisnu rhhuogt teh slne of a graneiln cvbjeeoti itque ety so eresh' ym 2 ncst:e mK si ECISNARDE cb ihst ntteaip ahs na nezmey ihtw an laelvor LEWOR ntyaifif c(an eb ertrocecd ot anrmlo treaf an sneireac ni rtabe)utss ichhw is itccrtacharesi of EPTETCMIVOI nb,tihniiio hwhci is yhw hte neli fo hte p.t is eno of eivtcepomit obniiinthi on a LB olpt
ehT qnetsoiu is yalbialsc isttegn pu a aniittsuo lirsmia to atht of a teicpevitmo tiobiinr.h hTye sya thta higher nrosiaccnoentt of ixarodylp thasophep rasceensi eht ytiavitc of teh enmyez ot arnoml evse.ll Siriam,lly ewnh uoy heav a ptoimeevict obinhirti dan aecrisen het oertcaicnnont of tesrutb,sa het eymnze anc eivehac hte sema axVm sa if othtiuw eht bnhirioti.
rmeemReb 1) emectivpoit srnithobii ~ neils ossCr at se- )rctyeitn2 i-Notpteniocmev shoinbrtii ~ on nlei cross
ngoL raenws ,hdaea tbu brea iwth e.m
HN:IT v lsook idnk fo ekil y, ewerahs k lkoos oerm elki x.
t-terpcnyie = mV1/xa
-epnttxcire = 1/Km
oetN ttah m,xaV sa a urmeesa fo cafomre,pnre cna eb edtlear ghrouth aynm ishtng. Mwil,eaenh Km si a set ihrectarcsicat of eht ,zemyen nad antnco eb le.retad
nI htis exp,emla eht ynezem mneprreaocf ax(mV) si esnaecdri yb nirgeincas hte tnavmii caotocfr os atht it caserhe a nl"m"rao yvctii.at o,Herwev eth yzeenm si llist leytnnerhi htytsi ude ot a canointegl e,ctdef so het mK stays hte easm.
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