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makingstrides
Macrophages secrete Il-1,6,8,12 and TNF - alpha.
In this scenario, the patient is Il-12 receptor deficient. When macrophages engulf an object, it releases Il-12 to stimulate T-lymphocytes, that in return, release Ifn-gamma, which would convert the macrophage into an epithiliod histiocyte.
+4
abk93
making strides is a baller Thank you
+
abk93
why is this patient il-12 deficient?
+2
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bbr
and (just for completeness), promotes Th1
+
ege
what does "Mac" stand for? "it will increase the mac molecules of the surface of the cells." Thanks!
+
saqeer
mac= membrane attack complex
+2
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submitted by โtrazobone(97)
I was so fixated on the fact that in a TB granuloma, macrophages produce IL12 or TNFalpha, not IL1. So I eliminated C and clicked B, even tho itโs not CD4 lymphocytes that produce TNFalpha. But the fact that macrophages produce IL1 still didnโt make any sense.
I couldnโt find any explanation in first aid for this (it doesnโt tell you what cells secrete IL1), but according to my notes from an immuno lecture I half paid attention to, IL1 is a cytokine of innate immunity secreted by monocytes, macrophages, endothelial cells, and epithelial cells; so basically everybody. This goes in conjunction with everything that FA says (FA18 p. 108)