fa 2019 pg 662, Inhalation injury and sequelae. in the inhalation injury and sequelae part they say signed nasal hairs or soot in the oropharynx -> decreased activity of airway cilia as there is soot overlying them and cant function properly tobacco has silica (fa 2019 pg 663) - silica can disrupt phagolysosomes and impair macrophages -> decreased alveolar macrophage function as for the increased mucus production and secretion - idk i figured there is an irritant and your body will be trying to clear it some how, i guess think about COPD

Can anyone explain why macrophage activity would be decreased in this? I wanted to pick one that had both mucus secreting activity as being increased along with increased macrophage activity with concomitant decrease in ciliary activity but this wasn't an option so I went with all increased. Since it's well-established that macrophages cause damage in emphysema (especially in smokers due to constant irritation from the smoke), how is it possible that macrophage activity would go DOWN?

Abnormal phagolysosome fusion in pulmonary alveolar macrophages of rats exposed chronically to cigarette smoke.

https://pubmed.ncbi.nlm.nih.gov/6206755/#:~:text=Cigarette%20smoking%20is%20strongly%20associated%20with%20functional%20and,antimicrobial%20activity%20of%20these%20cells%20might%20be%20diminished.