NBME Answers : bronchophony's page

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+3 visit this page (nbme24#50)

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Why not clinical trial? They could report a rare adverse effect in phase 4 clinical trial right?

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sunshinesweetheart there's no control group. it's just a case study. x3 +3

sunshinesweetheart plus clinical trials at that stage would have had tons and tons of participants (and, most importantly to rule out all the answers, control group) +1

servage I totally thought it was phase 4 of a clinical trial as part of post-market surveillance. Smh. +3

loaloagubba For phase 4 they report to the said findinds and adverse to the FDA via a portal not to a journal. +1

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submitted by haliburton(224), visit this page

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This is water intoxication. https://www.ncbi.nlm.nih.gov/pubmed/1877579

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thisisfine Agreed! It's along the lines of those marathon runners who collapse questions. Nothing but water for 24 hours = getting rid of too much sodium. +2

temmy are we just going to ignore the diarrhea for 3 days? what is its significance +4

kard Temmy, We aint Ignoring the Diarrhea, Actually the most likely electrolytes to get lost with it is sodium> chloride> potassium> bicarbonate... Plus the Water intoxication -> HYPONATREMIA +1

bronchophony why not hypoglycemia? +1

saulgoodman Because glucose is not an electrolyte, it does not conduct electricity in solution. The question is asking "Which of the following electrolyte abnormalities". +4

skonys @bronchophony assuming she doesn't have a glycogen/gluconeogensis prob, she wouldn't be hypoglycemic after 24hrs. FA91 +1

submitted by sweetmed(157), visit this page

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The chemotactic factors produced by monocytes and mast cells and the local vasodilatation stimulates neutrophilic chemotaxis. Also, endothelial cells activation further aggravates the inflammatory response and migration of neutrophils. This leads to an influx of neutrophils locally.

refrence: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512152/

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bronchophony Why not complement activation? +3

joyceeepan the way i though about it was: you need antibodies (IgG/IgM) to activate the complement system. But there's no such a thing as an anti-gout antibody. (and it is not an infection neither) +3

an_improved_me Thats not exactly true for a couple reasons. I saw a UWorld question that said something along the lines of an ApoProtein being useful b/c it binds the urate crystals, and makes it less likely for the crystals to be opsinized/recognized by neutrophils. Therefore, Abs do play a role. Secondly, you can have activation of coplement via the alternative pathway, which does not require ABs. +2