The chemotactic factors produced by monocytes and mast cells and the local vasodilatation stimulates neutrophilic chemotaxis. Also, endothelial cells activation further aggravates the inflammatory response and migration of neutrophils. This leads to an influx of neutrophils locally.
refrence: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512152/
Can't histamine also cause swelling or is it just not involved in the pathology of gout?
submitted by โneonem(629)
This is a case of acute gout. Monosodium urate crystals are taken up by neutrophils, leading to an acute inflammatory reaction. T-cells aren't really involved in gout (more rheumatoid arthritis).