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nbme24/Block 2/Question#44

A 35-year-old man with quadriplegia develops a ...

Area labeled ‘B’ (Proximal convoluted tubule)

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submitted by neonem(263),

Aminoglycosides are nephrotoxic; nephrotoxic chemicals/drugs cause acute tubular necrosis (ATN), characterized by damage to the PCT. ATN causes the formation of brown, muddy, granular casts in the urine. The fact that this patient is a quadriplegic might be suggesting that they have a lower volume of distribution for the drug (and therefore higher blood concentrations).