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NBME 24 Answers

nbme24/Block 2/Question#35 (48.1 difficulty score)
A 55-year-old woman comes to the physician ...
Lower motoneuronsπŸ”,πŸ“Ί
tags: neuro 

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submitted by therealslimshady(30),

Here is my personal way how I reasoned to the correct answer, if it helps anyone. First off, I recognized she probably has ALS, as she has purely motor symptoms (no sensory symptoms) that include both UMN (3-week history of muscle cramps) and LMN lesions (fasciculations, atrophy). In ALS, you have damage to anything that is composed of UMNs and LMNs. UMNs are found in (A) cerebral white matter, (B) corticospinal tract, and (C) internal capsule. I picked (D) for two reasons: (1) she has more LMN symptoms than UMN symptoms (the only UMN symptom was muscle cramps), and (2) choices A, B, and C are all UMNs, and so they can't all be right.

That's just what was going on through my brain. Very convoluted I know and might have errors, but if I helped at least 1 person then I did my job.

xmen  done, thank you +  

submitted by tinydoc(244),
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I ont'd hitnk it amtrtse wehrhet or tno thsi swa LAS ( hciwh I tlisl khint ti ).si Btu sethre soaifsclnatiu and Wseanesk nda rthpoya osteh rea MNLL .sgsni ehsrTe ooso nmay ekysan seiunsotq in stih axe,m tshi isnt eon fo .emth

submitted by rainlad(25),
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I swa nothrw ffo seucaeb I nd'tdi iezerla olwer nertnooomu = rlowe rotmo nnuroe afce mlap

L"MN .die.scti.f aa,riydrsth aipay,dgsh amsieycmtr imbl e,wskenas softiunciaas,cl hapyrot

MNU fdsc.tei..i sreduboaulpb ypals .(.ie ,sriatahdyr s,yapgdaih omteionla iiylt,bla sitascp atg,i ncso"u)l]

-- AF 2901 5p1.8

submitted by sattanki(72),
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oDse yannoe ehva yan deia on sthi to?qienus hhtguTo ti aws SL.A

ankistruggles  I thought it was ALS too (and I think it still could be?) but my thought process was that a lower motor neuron lesion would be the more specific answer. +2  
sattanki  Yeah makes sense, just threw me off cause ALS is both lower and upper motor neuron problems. Corticospinal tract would have been a better answer if they described more upper motor neuron symptoms, but as you said, they only describe lower motor neuron symptoms. Thanks! +6  
mousie  Agree I thought ALS too but eliminated Peripheral nerves and LMN because I guess I thought they were the same thing ....??? Am I way off here or could someone maybe explain how they are different? Thanks! +1  
baconpies  peripheral nerves would include motor & sensory, whereas LMN would be just motor +15  
seagull  Also, a LMN damage wouldn't include both hand and LE unless it was somehow diffuse as in Guil-barre syndrome. It would likely be specific to part of a body. right??? +1  
charcot_bouchard  No. if it was a peri nerve it would be limited to a particular muscle or muscles. but since its lower motor neuron it is affecting more diffusely. Like u need to take down only few Lumbo sacral neuron to get lower extremity weakness. but if it was sciatic or CFN (peri nerve) it would be specific & symptom include Sensory. +1  
vulcania  I think it's ALS too. The correct answer choice here seems more based on specific wording: the answer choice "Corticospinal tract in the spinal cord" wouldn't explain the tongue symptoms, since tongue motor innervation doesn't involve the corticospinal tract or the spinal cord (it's corticobulbar tract). This is a situation of "BEST answer choice," not "only correct answer choice." +  

submitted by guillo12(48),
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e"Th sslo of lrweo otorm rneouns lsead ot eekasnws, tgnchitwi of lmuesc ,iiuftalnoas()cc adn sols of cmleus smsa lusm(ce h)pto.ayr"


submitted by an_improved_me(64),

I figured since the answer was mis-spelled, it couldn't be the answer.

submitted by tissue creep(116),
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I trdeaet ihst klei nridnegW oaS/HmMffAn guo"tn(e c"fcs,oiuasntli)a nda sjut nkdi fo dacptcee ti engib eidrw ot be ni a lryd.a-5eo5-

dr.xx  SMA4 (Adult-onset)? +