NBME 24 Transforming growth factor-β (NBME Answers)

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Retired NBME 24 Answers

nbme24/Block 2/Question#36 (reveal difficulty score)
A 27-year-old woman comes to the physician ...
Transforming growth factor-β 🔍 / 📺 / 🌳 / 📖
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submitted by ∗brethren_md(105)

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TGF-Beta is an important fibroblast growth factor. Pathoma Ch2, page 20.

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+1 upvote downvote
submitted by ∗seagull(1933)

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This is either a hypertropic scar or keloid. Both arise due to over-expression of TGF-beta.

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charcot_bouchard i think its a foreign body granuloma +13

curbstep If it is then would Tumor Necrosis Factor be valid answer as TNF-a is involved in granuloma formation? +

azibird Because it specifically asks which subsgtance THAT PROMOTES FIBROBLAST MIGRATION AND PROLIFRERATION. I believe both TGF-b and TNF-a would be involved, but only TGF-b has this effect of fibroblasts. +2

unknown001 this is foreign body granuloma. look at the question . "Wwhich of the ff promote fibroblst migration and prolif. ? " does TNF do that ? NO. does TGF B do that ? YES +

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submitted by snafull(6)

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Can somebody explain why this is not a foreign body granuloma?

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yb_26 because they mention scattered fragments of foreign material (pt presents 2 months after c-section, sutures are either removed in 1 week or dissolve in few weeks (depends on type of suture material) +

suckitnbme I think it IS a foreign body granuloma. The sutures are supposed to be removed or dissolve but sometimes one gets left in. The question says foreign material and sutures are often polarizable. +5

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