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NBME 24 Answers

nbme24/Block 1/Question#39

A 40-year-old man with AIDS develops severe ...


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submitted by neonem(372),

Somatostatin is normally secreted by D cells in the pancreatic islets and GI mucosa. It basically blocks everything GI-related ("encourages somato-stasis"): decreased gastric acid & pepsinogen secretion, decreased pancreatic and small intestine fluid secretion, decreased gallbladder contraction, decreased insulin & glucagon release.

Decreasing gastrin release blocks the increase of GI motility (increased GI motility is the inherent problem of diarrhea).

The drug in the question is probably octreotide.