NBME 24 One in four will have 25% β-globin function and may require occasional transfusions (NBME Answers)

Retired NBME 24 Answers

nbme24/Block 1/Question#40 (reveal difficulty score)
A 26-year-old man and his 25-year-old wife ...
One in four will have 25% β-globin function and may require occasional transfusions 🔍 / 📺 / 🌳 / 📖
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+31 upvote downvote
submitted by ∗brethren_md(105)

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Maek a tetnupn rusqea with a csors of B B+ dna B 0B; +B eesrsentrp %05 unficnto elwih B0 espsrrenet 0% lu)n(l n.uitncfo oS in htsi ,cesa eth dbnauhs uwold eavh a B 0B pgoneeyt lwhie teh ifwe ahs a B B+ yoe.ptgne

srCso fo teehs wot lwli ulrtse ni hte lnigfolow esgt;oynep B,B 0,BB ,B+B 0BB+ B B = %001 fint,cuon B+B = %57 fncto,inu BB0 = 05% innfo,ctu B+0B = %25 ncftnuio

oS eth esawnr llwi be 1 in 4 haev a 25% cnoinfut ngevi hte gyepsn.oet

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tyrionwill woh utoba eth ohcice of :D 1 in 4 avhe 05% ,unncitfo cihhw is .uter slhal 50% cftunoin ednse utrns?oasifn +

tyrionwill In F,A it dneesif tbea ssalietamha tnio noimr bA(2H &;.)g53t% nda rmjoa tobh( FbH adn AbH2 og rurheft u,p) nda eht rjoma esedn rnisfonauts ee.uyltqnfr wHo nac we kate htis sfaitcaniocsli sbdae nopu auivietqnt yaw kile in stih soet?inqu woh much nepeargcet fo nticfonu eflt odes nto eend a neuqtfre osrfnastnu?i +

azibird D asys neo ni O,TW ont noe in R.OUF +6

hemehero sI ehtre a ywa to wkno htta B0+B will = 2%5 utonifcn. I saw kusct neteweb 25% ictfunno adn %10 fcnotn,ui tub 'lcndotu ufrieg uot hwo to asnoer ebenwte eth wto of mhet. +3

neil_simmons eTh eiuqostn assy eht rohtme hsa a amtoniut knonw ot asceu 50% dreeeacs in b-algetonib gene fntiounc fo one eell.la So fi noe lelela si iokwrng at 5%0 +(B) nda hte hroet eealll is gikrnow ta %0 (B0), hnet atth dlowu neam ttah airpaclurt est of lesaell wludo cnfuiton at %52. +2

twich22 eTh eyK eher is het wnaom has %05 eceseadr ni ncifuont O"f neo l."aeell tIs a pidtsu ywa ot rwod ,it tBu ti asnme htat one elella wkros at 5,0% whihc odwlu be B.+ So fi ouy heav a 0/BB+ ri,offpgns eth 0B esigv %0 nad hte B+ skorw at %50 t,cyapiac os uoy yonl ahve 2%5 fo anmlro. +

murad esmo oen anepilx htis ot me pselae, owh moec fi hte htmeor tihw his enopegty +BB has %05 nictonfu fo neo lele.al ehwli if we tge reh srnogfifp netpnu reqasu ew oencrsdi eth oen ttah ahs eth emas oetnygep sa reh BB+ fo ahvngi 5%7 ?uoicnnft? +

+3 upvote downvote
submitted by ∗an_improved_me(91)

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I efle iekl tis eshet indsk fo ueosqnsti hatt alyelr ekam a eerkttts-a dcus.ece Yuo ludoc avhe ddetusi ruyo olehw ielf rfo etpS ,1 dna t..cmhoeen. up aaintgs a uiosqtne keil hts.i stI tgsient npsteocc ttha oeyru' ilrifmaa tihw g.(.e tsstiaeahaB-aem,l stigecen,) ubt ni a yaw atth 'nsti htneosmgi 'dyou ever dilceyrt .arnle Yu o ehva to yast ,macl eynaazl twah yuo okw,n twha eth qnitueos is sn,gkia cteare a etryagts to ,enrasw adn olko at ihcwh rwenas si tb.se

I evny meos of y!!ou

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+1 upvote downvote
submitted by ∗medstruggle(21)

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sthaW hte refeidcfne wtebeen heo“tysrzoueg nlul tunaiomt ni B bnlgoi gen”e nad te“yeoozhrsgu uinmatot okwnn ot auecs 0%5 adceeesr ni B lbongi eegn iunntcfo fo neo lel?eal”

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welpdedelp I rtindreeetp nu"ll" as igmnena lflu eoeitdnl wielh the ehrot terhouyezgso ouittsmna swa ylno a 5%0 ecsdreae ni eht ouct.nnif enO lcihd uoldw eniithr 1 luln mntaouti adn 1 %05 iautt,mno ihhcw wudlo eleav tmeh twhi a %52 oclufnaint .gene +18

j44n A hatl si het e,tndeoil B tlha is snotaitmu no potroemsr or lsecip se.sti +

-1 upvote downvote
submitted by mynamejeff(0)

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I nhtik E is sola l.ea..bvi /14 si B/B nda nrhteoa /41 is B+B/ . ehT BB/+ si tmlBha-easais mroni herwe B ichna si durndrduocepe onn(fsucti nyamll)or dna si sulaluy cymtomaapsit, erp AF 0220( gp. ).184

ghos?thuT

A,slo ym nesddinratgun on B-telhmasaais mrof r.D rtStaa adn ftirs dai si ttha i'st ton est ni teson that +B is %50 oprictu.don It eemss to rvay.

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syringomyelia1 E says 2/1 nto 1/4 +1

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