Make a punnett square with a cross of B B+ and B B0; B+ represents 50% function while B0 represents 0% (null) function. So in this case, the husband would have a B B0 genotype while the wife has a B B+ genotype.
Cross of these two will result in the following genotypes; BB, BB0, BB+, B+B0
BB = 100% function, BB+ = 75% function, BB0 = 50% function, B+B0 = 25% function
So the answer will be 1 in 4 have a 25% function given the genotypes.
Whats the difference between “heterozygous null mutation in B globin gene” and “heterozygous mutation known to cause 50% decrease in B globin gene function of one allele”?
welpdedelpI interpreted "null" as meaning full deletion while the other heterozygous mutations was only a 50% decrease in the function. One child would inherit 1 null mutation and 1 50% mutation, which would leave them with a 25% functional gene.+52019-05-28T21:56:55Z
to snoo-finity ... and beyond!
submitted by brethren_md(60), 2019-06-02T18:55:58Z
Make a punnett square with a cross of B B+ and B B0; B+ represents 50% function while B0 represents 0% (null) function. So in this case, the husband would have a B B0 genotype while the wife has a B B+ genotype.
Cross of these two will result in the following genotypes; BB, BB0, BB+, B+B0 BB = 100% function, BB+ = 75% function, BB0 = 50% function, B+B0 = 25% function
So the answer will be 1 in 4 have a 25% function given the genotypes.