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NBME 24 Answers

nbme24/Block 1/Question#35 (reveal difficulty score)
A 1616-g (3-lb 9-oz) male newborn is ...
Bronchopulmonary dysplasia ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: newborn

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 +7  upvote downvote
submitted by โˆ—osgoodschlatter10(41)
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Baby developed RDS --> guven O2 as Rx --> complications of O2 herapy in neonated = RIB (FA 2019) R = Retinopathy of prematurity I = Inraventricular hemorrhage B = Bronchopulmonary dysplasia

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peridot  RDS (respiratory distress syndrome) and O2 therapy complications are described on p.647 in FA 2019! +2
peridot  This is due to free radicles, which is also briefly touched upon on p. 210 of FA 2019 +
peridot  radicals* +1
j44n  also I saw on one of the other NBME's that retinopathy is more likely than the intraventricular hemorrhage. I did some reading and found that the eyes adapt to local changes faster. So when you give them 100%02 their eyes get used to the elevation in 02 so when you take them off of it they upregulate a ton of VEGF to try to normalize back to the level they were used to on the 100% +3
jbrito718  Stevie Wonder is a victim of retinopathy of prematurity +3



 +4  upvote downvote
submitted by โˆ—seagull(1933)
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This infant has oxygen toxicity due to free radical generation. Free radicals damage the lung parenchyma leading to fibrosis and dysplasia (abnormal growth).

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link981  Per American Lung Association: Bronchopulmonary dysplasia (BPD) is a form of chronic lung disease that affects newborns (mostly premature) and infants. It results from damage to the lungs caused by mechanical ventilation (respirator) and long-term use of oxygen. Most infants recover from BPD, but some may have long-term breathing difficulty. + Prematurely born infants have very few tiny air sacs (alveoli) at birth. The alveoli that are present tend to not be mature enough to function normal, and the infant requires respiratory support to breathe. Although life-saving, these treatments can also cause lung damage. +3
jimdooder  Just to follow up on the concept, you would prevent this from occurring by decreasing the Fi02 to mid-low 90s. I believe this is tested on another form. +2



 +3  upvote downvote
submitted by rongloz(7)
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I think this is much simpler and is testing the understanding of basic path concepts of metaplasia and dysplasia. The question stem says there is bronchiolar metaplasia, and dysplasia is a reversible state of cells caused by longstanding hyperplasia or metaplasia (here in this case the baby presents 1 month later after the initial biopsy)

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flvent2120  I got this question wrong myself, but the second I looked at the vignette when reviewing, I noticed metaplasia as a hint toward dysplasia as well +



 +1  upvote downvote
submitted by โˆ—link981(208)
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Per American Lung Association: Bronchopulmonary dysplasia (BPD) is a form of chronic lung disease that affects newborns (mostly premature) and infants. It results from damage to the lungs caused by mechanical ventilation (respirator) and long-term use of oxygen. Most infants recover from BPD, but some may have long-term breathing difficulty. + Prematurely born infants have very few tiny air sacs (alveoli) at birth. The alveoli that are present tend to not be mature enough to function normal, and the infant requires respiratory support to breathe. Although life-saving, these treatments can also cause lung damage

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waterloo  per American Lunch Assoc... maaaaan what do I need to be to get this question right, a pulmonologist? +6



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