SSRIs produce a sustained increase in extracellular 5-HT in the dorsal raphe (DR), and this leads to autoinhibition of serotonergic neurons.
This is ridiculous but I could never keep these straight so
meet my family:
Achey grandpa Meynert
Dope cousin VT with a side Ho* (who's names are just initials) SNc
Uncle and aunt Raphe and sara
Cousin Gabby always screaming Na-Na-Na
norepi reminds me of the color blue, so locus ceruleus
Serotonin is synthesised at the Raphe nucles. Hence, Fluoxetine which is and SSRI will prevent Serotonin synthesis since it maintains a high level of serotonin in the synapse.