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nbme23/Block 2/Question#45

A 61-year-old man is prescribed fluoxetine for ...

Raphe nuclei

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submitted by dr.xx(44),

SSRIs produce a sustained increase in extracellular 5-HT in the dorsal raphe (DR), and this leads to autoinhibition of serotonergic neurons.


davidw  Pg 483 in firstaid has a good table of where the neurotransmitters work +1  

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submitted by sugaplum(57),

This is ridiculous but I could never keep these straight so meet my family:
Achey grandpa Meynert
Dope cousin VT with a side Ho* (who's names are just initials) SNc
Uncle and aunt Raphe and sara Cousin Gabby always screaming Na-Na-Na
norepi reminds me of the color blue, so locus ceruleus

paulkarr  LOL. Achey Granpa Meynert. I'm gonna steal this from you. +  

Serotonin is synthesised at the Raphe nucles. Hence, Fluoxetine which is and SSRI will prevent Serotonin synthesis since it maintains a high level of serotonin in the synapse.