- Lymphocytes are the most sensitive cells to whole body radiation
- Granulocytes (Mainly neutrophils) are particularly very sensitive to chemotherapeutic alkylating agents (requiring G-CSF shortly after)
Another way to approach this is asking yourself which of these cell types are likely undergoing the most mitotic activity. The granulocyte precursors are likely dividing more than nerves or lymphocytes (in absence of infection). This was my approach.
One of the side effects of Cyclophosphamide is myelosuppression.
See full list of side effects below:
cystitis and bladder cancer,
prevented with mesna
(sulfhydryl group of mesna
binds toxic metabolites) and
This question is asking how much reserve capacity there is of each compartment, of which the granulocytes have the least.
Note that myelosuppression can refer to any lineage (including lymphocytes).
Another way to look at: this question is essentially asking what is the MCC side effect of chemotherapeutic agents in general? Answer = bone marrow suppression thus affects granulocytes.