ohudrteyi icsk myondrse is eitmmsseo dlcale "olw 3T me"dns.yor losA oyu wkon atht teh pttiena si ertuihoyd abueecs her 4T adn STH rea winith het rneeefecr e.ganr She si .cisk

I ma fro emso seoarn gelinrna uaotb htsi orf hte strfi time so ll'I ritwe a bit obaut ihoerudty scik onyrsdem in scea ti pshle oonme.es

'Its a aiesesd fo lcioxneus - eth drohtyi hnrosmeo are whcak but teh hriyotd lnagd itefsl semes ot be ltyolat .nfie ycplfaieiclS, T3 selvle rea l,wo 3rT si ghhi the( tyiiactv of itefdefrn sodeaisdien rae ff,o os T3r is daem orme nda deaerdgd less, uhhotg it d'etosn mees kiel eth rT3 eellv has yna rteoh iicnallc piio)sl.inatcm sA hte terho menosmct ehva ineeontm,d STH adn 4T rea talclyypi malo,nr tlgohhua ethy can be saeedercd as lewl in eresev assc.e

udhyritoE sikc mydneosr is iylpyactl edu ot an nenidryglu ariclcti lelsnis ro vsaattroni - eht odyb ostps iknmag eth shromeno as an etemrxe arusmee to eavs geenyr adn ousrrcees. hTe rmettenat is to rteat hte ilndnguyre sl;selin ohiytdr hnoeomr thayrep si ton edeconemrmd as ist tsneecvseiffe is eoulc.visncni

nI htis tuioneqs esm,t the eattnip sha na yinglendur s.senlli Hre yiorhdt nlagd orwks einf (epdnsrso paieptylpaorr ot S)TH. sslaCic esca fo ohtiruedy scki .symredno

neviG htat rhe 4T evsell era m,olran ew cna ruel tou ,B ,D nda .E I'm a udmmdu nda utp C seabuce I ahd on daei atwh dueioythr ikcs eosrmndy wa.s uBt ginve tath ehr HST elevl si asol loranm, is't nto an iessu with the asaluhtmoyhp or aptiuiytr alg.nd

cuSero:(s iiwk pega dan this ritalec)

ihoruytEd iksc sordeymn = elesvl of 3T oadn/r 4T rea nrmalabo, but eht tohyird dlnga dsoe nto paraep to eb nlt.onscyfiuda hTe sacicllsa hpeteynpo of ihst iitonncod is tfnoe esen ni snartatvoi, tccriial ,elnisls or isnpaett ni the venisneti arec niu.t Teh otms mcnomo mnohroe ratepnt is wlo toatl dan efer 3,T evedaetl T,3r nad laonmr T4 and SHT ell.sev

nI oheuyitdr ksic ermdoyn,s heetr wlli be arnlom 3rT, low T,3 nda amnrlo HT→S hsit si bsueeca in ccatiilr ensisll tehre is eedsdcrae ayttcvii of D1D2/ eoam-sioneon5did acityitv ar(lyomln 4T → ,3T and 3rT → T)2, n ad nicsdeare vtticyai of D3 5' eaoneimdsndooi ylalnm(ro T4 → Tr)3

staeiPtn wiht vseere irhtEoduy Skic monedySr amy vhea low free ,4T lwo altto ,4T ADN owl THS vleels

dEiothyur skic nesoydmr

eDu ot: esevre steiymsc sseinll e(i)psss

:hPta keyicnots (-I,L1 aNTF, 6L-I) --;> adersecde liparhrpee eoins-ia'ed5d *

as:Lb oramln TS,H mlanro T,4 owl ,T3 ghhi 3Tr llrace( ahtt T4 cna be cveerodnt to therie T3 or rT3.)

*ehetr era nyma ensicmamsh hatt dael to ;htsi ,ovwehre iths is teh tsmo lncyaillci neltaver rfo lbsa