NBME 21 Nuclear/cytoplasmic shuttling: yes;<br />Serine phosphorylation: yes<br />Ubiquitin-mediated proteolysis: no (NBME Answers)

Retired NBME 21 Answers

nbme21/Block 4/Question#4 (reveal difficulty score)
The FOXO transcription factor responds to ...
Nuclear/cytoplasmic shuttling: yes;
Serine phosphorylation: yes
Ubiquitin-mediated proteolysis: no 🔍 / 📺 / 🌳 / 📖
tags: biochem

+13 upvote downvote
submitted by calcium196(12)

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ibdaedmt-utiUqieni rsitpoyolse is nto vbyseeirlr aedtfecf yb iinnsu.l The squetnio sask for ebesrerivl aysw atht uilnsin sfecfta ti, dan nibouatntiuiqi loduw alde to gddairtenoa vai esestpo,ra hihcw is ton ibrrvee.lse /raltNeycsacipclomu tuinnhsg maske esnes baeecsu XOFO is a oitpnansrrcit oftc,ra os it nt’ac do sti boj if it is in eht ysatlpo!mc

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meningitis nahTk yuo fro ryou plnen!iaxtao nO e etnquo:si Hwo tubao eht niesre pstaonoprhyl?oih sI ti wsadeenr yb erup atmroezimion that hte XOOF FT is nseire ho,ateholprdsyp or si it a renaegl fact htta lal s'FT era isonnenre-rtheei yepolht?arphsod +

tsl19 mI' ont se,ru btu ti mya be sa mpilse sa hits: unmeutbdiqitdea-ii seplyisoort si rrielsrevi,eb tub tobh CN/ lguhsttin nad ayphohploiontsr rae llaneryge eirsvblere esepssco.r +

didelphus I slao edguses that OXOF stum be a ratp of eth 3KIP ,yhtpawa ncsei inilusn eugtsarel saimtlembo hrtohgu 3PKI adn eht itsneqou tsme pilciayslecf nnsioemt a.htt noopylPshohtrai is a mjroa tarp of tath phtw,yaa os vene dincityelr npoapohytlrshoi oudlw eertluga XF.OO gtsFtinarur uenito.sq +21

niboonsh e,sy OOXF si ffaedtce awnomtsdre of eht aiatnvioct fo P3.IK isTh is a rlayel oogd deovi hatt lxpseian eth wlohe deascac mtpv?o/=w/weuteLttugw/hcs:3acy4w.hs-d.wbN9o +2

alexb igcordAcn to iekpiidaw (ot/iri.ieewOk/wp/hgtiXk:pFai/dnO1.s) aptiysonpohorhl of 1OOXF si vrr.eielriebs ishT si einrgrref to ihtyanohospplro fo senier iseesdru on XOOF yb k,At chiwh sccuro ni neporses to inlnsu.i But eht MNEB aerwns sesusgtg 'tis ereeibsvl.r ha'sWt up? +2

almondbreeze udocl iwki be nwgro on plooiynhshoarpt ginbe r?everlsiiber occdigran ot ihts alcti,er it si a reeesvrbil :secsrop roualengti of FOox tropacirtsnin ocartfs by ieelbresvr ohronahtoispply adn ntoayalietc (4s0:10//78cmc00is61o.e0teipc/scenee571ea9icc38htipwlScnrd1sitw0/w0.ti/#/r m)seo kiiw nf,oi ,evrohwe si ehullfp : In sti ptrohahyudesnop-l ta,est FOX1O is zciadlole to the lcuue,sn herew it dbsni to eht ilisnnu rpenoses eenequsc ecltdao in the emrotpor for sglueco hse6tsa-aphpo dan ainersecs sit arte fo tnoiirncsra.tp FX,OO1 ghorthu neaiicnrsg iiapcttnrrosn of oa-h,ts-soelgc6hepasup itdelynric cserieans the rtae fo eatcihp ogclsue rco9pno[]d1.uit e,evrHwo hewn OOX1F si hyoepdtlophars yb tkA no 42,-hTr e-2r,S65 adn 3-S19e,r ti is ueddclxe form eth ulcues,n wrehe ti is then biudtiqaeunti dan .daegrded The htolishanoporyp of OFXO1 yb ktA ensstyuueblq resseaced teh iachetp euolcgs pturooidcn ugohthr a dseeaerc in ncrtpiosnarit fo seglcuo o.6-ahephssapt +

leaf_house It seems ekil teh oppnahltoiysorh fomr Akt edlas to rteouctdisn, tub aebmy teh stpnmsaiuo si ttha that hasnoiprolyopht tpse eiunl(cdgx veyre hreot spet of ismteiube-outnqipoor awphay)t is bseeie,lrrv wehre psriloeotsy is iafl.n hbinson@o iodve si ogod btu 'sdeotn tpils htis en.o +

+11 upvote downvote
submitted by ∗imgdoc(183)

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ihsT ostquien is kaisgn btuoa eth unlisni tcrorpee itosyrne esikna yhpa.wta oS ktae ti fomr reteh,

eTh tslpyaoorhiphon fo eht SIR icvtesaat a lnsgia nruitsactodn dcasaec atht edlsa ot the vicitanaot of throe iksnsae sa llew as tisatprrcnoin csatofr ttah aidteem hte tllcalinaerru tsfcefe of i.nnusli eclsoCpactNlriya/um hnultstig - sey evrbrlei)e(s
eoeTrenrihnSnei/ enkassi rae losa knonw to urceed teh tiyiavtc of ni.nsilu - yes r(elvrsie)be
ubiUqntii - eitdeamd sootrlpeysi - no (ton iere,blr)sev dan oasl lisinnu caeiytllabmlo crnsisaee netproi hysnesist os ti osten'd mchta wtha ulnniis dose w.ayyans

tceorrc em fi I'm .nogwr

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usmle11a i nthik yreuo ortcerc eacus ubtqiniui dadeeitm ptrsoylieo si na reiibseevlrr e.pst +1

+7 upvote downvote
submitted by ∗hello(429)

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eTh Q tmes attess OOFX si a tntrprasiiocn rfaotc taht dporness to isunnil gnnaglisi yb irglatne eth rnaoirpscntti of omtceblia egsne ;--g&t frehe,erot OXOF si a atostirnrnpci ofcatr eiolvndv in mio.eamtsbl Tihs ldoshu emak ssnee ucseaeb nenr-eiitcolspur vioactatin ash a erlo in iluatngreg liat.bsmmoe

Tish Q akss autbo rbeelisrev swya htat luiisnn atrgseeu XFOO nstcorptnrai ctoafr tyc.taivi

itdimteb-unUaieidq etpoysloirs si ierserirbvle. mlniaEeti all ehoicsc cteexp for ,B ,D dan .H

inolcIerpusn-tsre cinoufnt grhhtou KIP3 ngsilai.gn P3KI gsianignl lenvvois poantyporlhsioh fo nsiree t;&g-- rsenie nhrtohoilosyppa si a eisrblerev secrosp. naielmitE .H :YFI pnnritoemo/ai idac syhaporlnhtioop is ysaalw rvle.bereis

Yuo era ltfe tihw hcicsoe B nad D.

OOXF is a rntpiiotsnrca ctfaor ;--gt& nrocatiptnirs tsfroac eatemdi egen tcityaiv yb stnghitlu wenetbe eht cylaostmp dan len.cuus Rnugaetgil hte cotalnoi of XOOF trpiinsoncrta rfacto (..ei alsoptmcy vs. el)suncu wlil heorerfet sbvrieelry alemtuod daiFdOmeet-XO aocieblmt egne i.ativytc

iTsh ealevs oyu iwht the retoccr rnewsa: coeihC .B

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adong A tebert awy to tikhn uabto it is uilnsni satc hruotgh APMK hchiw is a rrneeneshieint/o knaesi +1

amy I tereteatinpd mcaN/Ccislyelrautop ilhgsnttu ouwdl be eht ltersu of enesir ntol,oyohairspph so hte erbrslivee miadfnootcii si noyl on esrnei hoihrpptsnloay,o icwhh laed to m/lcernacaitosucylp iuhntgt,ls utb hte gitutnlhs sietlf is not duner d.infIoicom iat ogt it g.rnwo +

+1 upvote downvote
submitted by ∗usmleuser007(464)

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iSnree olhhnsirptpoyoa lwli uedcer sniusl'in c.ftefsa tI ctas on het oryniets ksaein.

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alexandramda ge-0r/wpld-y7:h/S0m2p/nd/prb3o.(9fo00ts-t8l0uwicc.t9)896eow.0fc/2l +

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