NBME 21 Nuclear/cytoplasmic shuttling: yes;<br />Serine phosphorylation: yes<br />Ubiquitin-mediated proteolysis: no (NBME Answers)

Retired NBME 21 Answers

nbme21/Block 4/Question#4 (reveal difficulty score)
The FOXO transcription factor responds to ...
Nuclear/cytoplasmic shuttling: yes;
Serine phosphorylation: yes
Ubiquitin-mediated proteolysis: no 🔍 / 📺 / 🌳 / 📖
tags: biochem

+13 upvote downvote
submitted by calcium196(12)

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aiiinimtudetqe-dbU siestyrploo is ont vierybelsr teafcdef by nil.nius Teh nsqoueti sska orf reiebelrsv sywa htat ulnsini atfcsef it, and qunuiiiatbiton loudw eald ot digarteodan iav esserpto,a hihcw is ont er.eisblver olcyiscptauc/almreN nstgihnu ekmsa esnse eseaubc XFOO is a icttpnonarsri ftcor,a os ti tnac’ do sti job if it is ni teh spayc!tolm

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meningitis nakhT uoy fro oury ox!innaptlea e O n qtnieosu: oHw otuba hte isnree h?orooytlahipsnp Is ti weednars yb rupe moiizrmtnaeo ttah teh XOOF TF si inerse yrosahpphdoe,lt ro si ti a egnarel tfac thta all F'sT rea rienntioeheesr-n st?lohorhdypaep +

tsl19 I'm tno re,us tub it yam be sa semilp as isht: aiueitmtnduidbeqi- yoolssptrei is rriiee,brevsl tbu hbot NC/ ngslthitu dna hoprapysnotholi rae rgeayllen lsivebreer ospers.sce +

didelphus I aosl gdeuses ttah OXFO umts be a prta fo het K3IP aahytw,p cenis niiulsn eslgatrue biamleomts huhtorg PKI3 adn teh ieuosntq mset yscpilelacfi menostin ttah. otlihyasPhnrpoo si a aomjr ratp fo ttah ya,hptwa os eenv dreiyncitl hiotnoyrpplshao lodwu glraeteu FXO.O angtrFuitsr .iusqenot +21

niboonsh sey, OOXF si teafdfec arstendmow of the anttcaviio of P.IK3 sTih si a lraeyl dgoo oived atht ipxsaeln eth ohlwe sdcacae u:oowegwtsb?yvwuspt=./N.h4aLh3mcd9c/wwt/-te +2

alexb irAccndog to wdiakeipi (ndrppiFtsi.kO/kwg:1hiw/eO/ao.i/iXet) pnoohsotarhyilp of OFOX1 si rlreier.isbev siTh si rnefirgre to rnisppylatoohho of neeisr sseirued no XOOF by tAk, hwhci scoucr ni ropeesns ot sulin.in uBt the MNBE anrews susggset tis' rebeiesvr.l asth'W up? +2

almondbreeze locud wiik be nrgow on yoltooriphapnsh geibn berelsi?rvier gnricadoc ot htis r,latiec ti is a revisbeerl rsps:eco tlienugrao of xOoF rripancsiontt arcstof by esieverlbr royhapionspotlh nda ttlneiacoya (i10cr0ee8c/l60ts15prisdio0cn1sit9.8/4c7mt.3tw/0ci/c1p0hi#esa7/cewn/e0Se:wm oe)s ikiw onf,i o,wehvre si pehllfu : nI its so-rphltehduopany tstea, XOOF1 is dolleziac ot the cnes,uul erhwe it bdsni to hte nsiiunl nposeers uesqcene cedatlo in het rmerootp orf glscueo -sshp6tapaoeh adn ciensersa tsi tera fo ntt.iaspoirncr O1FOX, hutorhg sanrncigie srrtpinncaoti of -lphape,thgssoc-oseu6a dlynectiri isreecans eth rtea of hpticae glcsoue o1pridncu.][o9t oewvr,eH ewnh 1XFOO si lretdoppyshoha by tkA on -2rh4T, 56Ser-2, nda 3er-1,9S ti is edxeuldc frmo teh uu,selnc ewehr it si htne utidbuqateiin dna geea.rddd heT yoiplhohnoparts of 1XOFO yb ktA qtuylubneses eecsdsear teh pcietha elucogs nodcrtouip htuhgro a aedeserc ni itrosipnnacrt of oeglcus tahssheao.p-6p +

leaf_house tI msees eilk eth rhhtliapoynoosp fomr tkA lades to terudsc,onti but ebyam the oinpuassmt is atht atht lyppshrnhoiaoto tpes ci(egulxdn veery ethor pset fo tminesoiuipb-rooquet tyhp)waa is lebrrseeiv, ehwre pliseyrsoto is nfli.a obhosn@in oeidv si odog but t'onsde split sthi .one +

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submitted by ∗imgdoc(183)

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hTis qionteus is gkinas aotbu hte ninlusi retcopre sirtneyo einsak h.tawypa So ktea ti romf rhte,e

eTh opinyorptsolhha fo eht SIR tetaacsvi a gslian intarundocst caascde ttha adesl to the onicvatiat of oetrh eiasnks sa llew as snitricnatrpo rcsatfo that tmeidae het lluaneatcirlr cfesfte fo niu.nils /lelycraucaCioNtmsp hntgutsli - yse )rlsebiveer(
/oieeerTnennihrS sakneis era aols onknw to rucede eth tyvitica of .luinnsi - sey eee)sirl(brv
Uqnitbiiu - madetdei ioesostlyrp - on (tno )ir,rebelsve nad olas sniiuln aeblmoyltlcai snraceeis opirent yihsnsets os it nt'sode athcm wtah ninulis osed synwy.aa

ecrotcr me fi Im' .nogwr

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usmle11a i nkhti oreuy rtcecor cueas unibiuqti dteediam tlsoroepyi si an veiisrrleber .tsep +1

+7 upvote downvote
submitted by ∗hello(429)

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The Q estm easstt XOOF si a picisoantrrtn froact ttha prdssnoe to innsliu iialgngns by atrigenl het orciatpnrntis fo emabticlo neges t&-;-g or,eerefth OXOF si a iocsptarirnnt ofctar ieldnovv ni stelimb.oam hiTs hdlosu mkea senes eesuabc ltneseirirocnp-u itiovcnata ahs a role ni rgieuglant elbmaisto.m

hsiT Q skas auotb besrvreile awsy ahtt insluin sgateuer OFXO ticnapnrrtso facotr icy.tviat

taUneimiqieidbdut- osprlosyeit is lsierrireebv. mtaniElie all checsio xecpte fro ,B ,D nad H.

lcIuieesrn-rpnots ftnuiocn tghruoh KP3I gn.ilnisag PIK3 giagnlnsi neosvvil hloasotpnphroiy fo nirese &g-;t- ernsie sooriahpypnthol si a evselrireb osrec.ps lenmatiEi .H I:FY n/iipatmrneoo cdia pnsohyapoilhrot is yalaws ersevbri.le

uoY aer tlfe wthi occeish B dan .D

FXOO is a crnntistpraoi otacfr -;-gt& trntnaoipcisr oscftar aimeetd geen catviity yb gsithultn eewtebn hte yloasmcpt dna escu.nlu Rgeailugtn eth tcalonio of OFXO niactprsorint roctfa e.i.( lacomtyps .sv uesucnl) lilw eoreehrtf verebiyslr dtlemauo eFadmOOde-Xti lacoiembt egne iyvtcait.

hiTs vlseea yuo htwi teh ortccre earwsn: hcioCe .B

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adong A rbette awy to kinth autob ti is uinlnis tacs uhthogr PKMA hchiw si a reihorsetnnein/e aeiksn +1

amy I tiertdpentae pe/asrciCNylmluacot tshgnluit ulwdo be eht lrtues of sirene s,honoioppalrtyh so teh rresbleevi dfoncitimaio si olny on nesrie nospopilthaohyr, ihchw elad to yclaonscm/cupriltae tgsu,hntli but eth utsnhlitg setlif si ton denru idInoca.fito im tgo it ornwg. +

+1 upvote downvote
submitted by ∗usmleuser007(464)

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reSein lnytrahoiphospo wlli ueedrc nuis'lsni tcsfaf.e tI atsc on eth tisnoyer ina.eks

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alexandramda ll2ho(2/:epp-s7tp9//o)69uSow0mwt-/ly90d8.cc.be00t03rcdfwi-g8n0.rf/ +

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