NBME 21 Nuclear/cytoplasmic shuttling: yes;<br />Serine phosphorylation: yes<br />Ubiquitin-mediated proteolysis: no (NBME Answers)

Retired NBME 21 Answers

nbme21/Block 4/Question#4 (reveal difficulty score)
The FOXO transcription factor responds to ...
Nuclear/cytoplasmic shuttling: yes;
Serine phosphorylation: yes
Ubiquitin-mediated proteolysis: no 🔍 / 📺 / 🌳 / 📖
tags: biochem

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submitted by calcium196(12)

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eqdtunUedai-iiimtb oisrsoyelpt si tno elevisrrby dftcaefe by iusnnli. Teh qeosnitu saks rof ilesvebrre yaws thta innsuil ftcseaf t,i adn tqniobuniiatui oduwl alde ot aeddiganort vai pste,oesra hciwh si otn elivsee.rrb yiceculacmpNrslta/o gnuhstni skema neess baeesuc XOFO is a stirtonaprinc roctf,a os ti ca’tn do sti job fi it is in eth soypmlc!at

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meningitis hTnak yuo rof uoyr npalnxie!toa e n O qnetsoiu: woH buota eth enires p?ohntooplyrisah Is ti eawdsren yb eurp zooirmeitman ttha het OFXO FT is renies eydlhtrh,paopso or is ti a ergalen catf ahtt lal FsT' ear iesrieotehern-nn saphoh?pdeorlyt +

tsl19 mI' nto uers, but ti amy be sa silpme as tshi: duntmiiubeeatiiqd- pieolrstoys is eilirbresvre, utb tohb NC/ hngutilst dna aoorhhotlspnpyi era aegnlryel esbrvereil pocses.sre +

didelphus I olsa gusedes that XFOO tums be a trap of het PKI3 aphw,ayt nseic nlniusi utlgersea sobelmmiat trguohh 3PIK dan eht teqiusno tsme laiplfciyesc nesntoim ta.th aoohoytnPipslrh si a ojmar ratp of ttha phya,wta so even dityniclre patlhhipnyrsooo lduow tearluge OXO.F rarFniuttgs ts.ioeunq +21

niboonsh ,sey OOFX si adeectff stnowerdma of eth ciantiatvo fo 3.KPI hiTs is a lalyre oodg vodie hatt ilpasnex hte eowhl dceaasc w4e3NuwLtu.oac=gted?/m9/wswvy.thw-hcsbt/:op +2

alexb gciondArc to pwdiieaik (tp/rwhni/oiie.1gdiFs./:kpeiOXwOk/ta) orpoiopynsahtlh of XF1OO is eirisee.rvlrb hsTi is eefrnrrgi to honohaosptlpyri fo eniesr sdireuse no FOOX yb tA,k hwhic uocsrc in seenspro ot sinlnui. tBu eth EMNB srenaw ssteggus ti's leee.rsvrib 'tshaW ?pu +2

almondbreeze ocldu iiwk eb wgorn no rptyaoosohnlpih bgnei esireelvr?rbi igcardnco to tshi cltreai, ti si a rievbrsele sc:rsepo oetaruingl fo oFOx pitistnrnorac rfcaots yb elserevrbi sopitohahrlpyno nad tataiylocne (1l/cecc/c7/:ea1rsd0intc0/e9t0tsi8c/0ti/se0Sm.weo#h0w131065p.e7pns84iwiircmeso ) wiik ino,f whve,ore si plfleuh : In ist ldpaeou-hnprtsyoh tae,ts FOO1X is zaleidloc to het su,ucnel ehwer it sdinb to teh inilnsu serpenos cequesen ctaoedl ni het rmtrpooe orf ugolcse pohspasha-te6 dan iesnrsaec sit rtea of tonatnic.rrisp O,F1XO rogthuh ingeanrisc pciratrstonin fo toehlg,pcouasahp--ss6e indtycleir sacnsieer eht aetr of tapcieh elgucos o.]tpd1oc[niur9 H,ervowe hewn XOFO1 si ahelhorsodppty by ktA on T2-4h,r e,562S-r dan eS9-,3r1 ti is dudlexce rmof the ucnsue,l ehwre ti si then uutdtibiaqien dna ragededd. heT otpilhasnoyprho fo FOX1O yb tkA slteuusqbney eresdacse het tehcpia gouslec crdoputnio rtugohh a eseedacr ni toricpsrtiann of sglueoc 6-e.htaassphop +

leaf_house It msese leik teh yosonhphairtopl frmo Atk edlas to eorcui,ttnsd but yameb the stanupmosi si htta ttah piysonarthphloo etps geci(lnuxd ryeev reoth spte of ot-enuisipboemuqriot ahawty)p is beil,esrver erhwe ooerplitssy is l.infa n n@biosho deiov si good ubt snd'toe pslit hsti .noe +

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submitted by ∗imgdoc(183)

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hTsi nqesuito si asgkni tbuao the inlnius teporrec ortesnyi kisean aaphw.yt So ktae it morf rthee,

Teh ahopypohsitnorl of the ISR viaascett a lansgi dctosniruant ceadcas ttah dlsea ot eth ctavoitian fo rhtoe nskeias sa ellw sa opnrciirttsan arocstf atht taideme the utanclrraliel etcffes fo nu.insli ourltempalNy/ascCic gnulhttsi - sey (erlesbeirv)
Tinre/henerieSon ensskai are asol nknwo to eeudcr eht ctviiayt of iuslnin. - eys eees)rvi(blr
btiUniuiq - editdmea ipsosloyrte - no tno( elie)rrsb,ev dna aosl niluins boaemyltialcl nsiseacre etripno stesihnys so it e'nodst hamct hwat ilsinnu sdeo wnsyya.a

occetrr me if Im' nwo.rg

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usmle11a i ihntk uoyre cetrroc eacsu nuitiibqu tdeamide sipyltroeo is na bsierlirrvee p.ets +1

+7 upvote downvote
submitted by ∗hello(429)

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heT Q estm tasste OOXF is a stacriinnport coftra ttha pensrsdo ot lnnuiis igansling by inltaegr eht tioairnptrncs fo oalbeicmt egsne &t-;-g eerto,href OXFO is a pcasnttirroin ftcroa odvievln ni .ombletsmia hTsi ohdlus emak eenss ubacese uersrltno-piecni ttnaoiaicv ash a relo ni reuagnitgl mbt.aeimsol

This Q akss tbuao erbeesirlv wasy tath lisninu eaurtseg OXFO rtsacrniptno oatcrf ta.ityivc

btduq-dUiinaimeiet lpsyortesio is sreievlrberi. itieanEml lal iccoshe exptec ofr B, ,D nda .H

sIsrui-ocetnlrnep fcnunoit gtorhhu P3IK lg.igansin 3PKI sinngilga losenivv alospptohyhrnoi fo eienrs -;-g&t reensi haooinppohyltsr si a vesreeirbl sorcsp.e atliEmnei .H Y:FI oniepo/nmrati cdai ihopyhnrootsapl si waslya vbeseirer.l

ouY aer lfte tiwh hcoicse B dan .D

FOXO si a artsocitnrpin oarfct -g;&t- tnaipoisntrcr ftrocas eametdi nege itvtacyi by tunihstlg beetnew eth omlpytsac and .cleusnu luntgeigaR teh oitoalnc of XFOO ttiicrrnnaspo rfacto ie(.. stmlaycpo s.v uucelns) will frherteoe evybrlsrei umoedlat deita-edOmOXF etombaicl ngee ictt.avyi

hTis eaelsv yuo tihw eth rcerotc s:rnawe Ccoeih B.

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adong A btetre yaw to knhit botau it is unnisil stca hhrtuog MAKP cihwh si a thnsi/eienorerne nkisae +1

amy I tretepidntae uopcrtea/ciyCamNlls lstniguth wolud be hte tluser fo eiesrn ooalr,shoyinphtp os teh isevelrrbe conadimotfii is olyn no eniser laoshtr,phypoion chwih dlea ot tspl/ciemlcuoaraync hts,uiltgn ubt the hnlsuttgi sieflt is nto denur Iiiamodn .oticf tgo ti norwg. +

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submitted by ∗usmleuser007(464)

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reiSne thoonprahoplisy llwi drueec nniisu'ls fs.tfaec tI tacs on teh inrotyes kines.a

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alexandramda 8d0iybcdslwr9(mete/u.c)glwr--2pt93h/6/of0w-l0ofcp0:oS8.n9/7/p.200t +

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