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NBME 21 Answers

nbme21/Block 1/Question#43

A 52-year-old man is brought to the emergency ...

Histamine

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submitted by neonem(263),

Morphine is a mu opioid agonist - one adverse effect of opioids is mast cell degranulation that is IgE-independent. Release of histamine is akin to an anaphylactic reaction --> pruritis, etc.

sympathetikey  Never had heard of that one. Just a good guess. Thanks! +  
yb_26  IgE-independent mast cell degranulation can also be caused by radiocontrast agents, some antibiotics (vancomycin) +  
temmy  it was a u world question +  




Is this just red-man syndrome? Direct mast-cell degranulation caused by vancomycin....and also morphine?