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NBME 18 Answers

nbme18/Block 4/Question#4

36 yo woman, 2 weeks of fatigue, bleeding gums, bone pain

Histone acetylase

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Histone acetylation allows for relaxation of the DNA so that transcription can proceed. All trans retinoic acid causes the granulocytes in APML to further mature, which requires DNA transcription / translation.