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NBME 18 Answers

nbme18/Block 4/Question#4

36 yo woman, 2 weeks of fatigue, bleeding gums, bone pain

Histone acetylase

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submitted by sympathetikey(197),

Histone acetylation allows for relaxation of the DNA so that transcription can proceed. All trans retinoic acid causes the granulocytes in APML to further mature, which requires DNA transcription / translation.