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NBME 17 Answers

nbme17/Block 0/Question#0 (reveal difficulty score)
A 60-year-old woman is brought to the ...
Nephrolithiasis ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—cassdawg(1780)
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This woman has gout which is associated with hypertension and diabetes and attacks can be precipitated by diuresis (such as with furosemide). Negatively biorefringent crystals (uric acid crystals) are also characteristic of gout. Gout is associated with kidney stones (nephrolithiasis). [FA2020 p467]

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frijoles  I don't see where it says that gout is associated with kidney stones. Gout is more commonly caused by underexcretion than overproduction, yes? And this patient has renal insufficiency, yes? So if anything, they have LESS uric acid in the urine and are LESS likely to have stones. It's the reason they have gout to begin with (because it's out of the urine and into the blood). This answer would make sense if the gout was due to overproduction but there is no evidence of that here. This isn't a very good question imo. Please lmk if I'm missing something here. +3
jt263619  uric acid stones... +3
tyrionwill  hyperuricemia may cause kidney stone if urine turns to be acidic or condensed. so I think this question is asking a general possible complication. +
i_hate_it_here  I think that what they were trying to ask was what could also occur due to the predisposing factor that led to gout. The patient was on a loop diuretic which can lead to hypovolemia. Kidney stones and gout occur more frequently when the substrates are able to concentrate in low volume. +3
kard  furosemide and acetazolamid---> Nephrolithiasis! +1
millan  I thought it was osteoporosis due to calcium loss???? +
ibashli  I also put osteoporosis at first but I think that's with chronic use of furosemide. She has only been on it for 1 month so it's more likely that she will develop a stone from uric acid accumulation than osteoporosis from a little excess loss of calcium, especially because of her "Gradually increasing serum creatinine," suggesting that she is getting gradually worse and worse at filtering out the uric acid from her body --> worsening arthritis and risk of stones. +



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