These individuals have a poluymorphism in the breakdown pathway of 6-MP. Like most polymorphisms in drug breakdown pathways, this will lead to buildup of toxic metabolites unless the drug dose is decreased (i.e. the 6-MP will be shunted into the pathway that makes the toxic 6-thioguanine).
6-MP and its prodrug azothioprine inhibit purine synthesis (FA2020 p36 and p440).
ali_hassanmy pea-sized brain doesn't understand why not give injections of XO. help+2
harbourlightsthat's what I put. Because if you decreased their dosage wouldn't also cause a decrease in the final 6-TGN concentration making it less effective?+2
amira89what is thiopurine methyltransferase (TPMT) and where does it act? +1
submitted by โcassdawg(1780)
These individuals have a poluymorphism in the breakdown pathway of 6-MP. Like most polymorphisms in drug breakdown pathways, this will lead to buildup of toxic metabolites unless the drug dose is decreased (i.e. the 6-MP will be shunted into the pathway that makes the toxic 6-thioguanine).
6-MP and its prodrug azothioprine inhibit purine synthesis (FA2020 p36 and p440).