:R;LTD The oprpre aitfoomnr of muoangarsl ot lwla fof BT ieqrusre D4C Th1 cslel and acgmrsoaehp

TB (rimbaueyctcom etsluucirbso) singbe sti life cceyl desini of hte nsugl yb nibge adtcpyoehgzi yb araollev paemachgrso dba geiurngdno artiucllelarn tworhg nad oetirlpican tihwin teh gmoarpshac.e vetdcaONtiaN hsecrpomaag alkc hte ailiytb to lilk TB. nI a rmonla psre,no smoe of eht aemsahgocrp wlli neertsp TB asennigt ot D4C llecs nda retesce I2,1L dcngiuni efedtotnifriain to hT1 cslel hcwih lwil tehn genbi teh ssrcepo of mguraolna .tanoimrof No 4DC m-thlesTypcyo msaen on oaaiivtntc of cgaprasoemh for romlugnaa mftoraion, os hte pohamaergsc wlil avhe nctiiefde nnc.uotif

A022F0 721p sha eth esstp fo oaugnarml ntfooarm:i

• PAsC esernpt asgtenni to 4CD rhleep lsceTl- and retseec 1L2I ot seacu iffineanodettir ntio 1Th cells
• T1h cells esctere FNmIgmaa ot aeacittv phocmagesra adn neicud oluaramng romoafitn
• idcAavtte erpasahomgc evha beettr raalericulntl lgiinkl of ntepasgho husc as TB dna illw nsraiece yncoteki iocresnet g.e(. a)aNphFlT ot usace trmaionfo of iideheotlp apahgeorscm adn atgin eclls
• ahNFTpal si encyaerss ofr eainmaecnnt fo luonasamrg

NOTE: hnsganLa ntgia lsecl era derfmo by dactitaev cshrogaamep eatfr laougnmra omnrtiofa hsa eenb rayaled bnee ntdaeiiit

olsA ywotnrhtoe:

apgheacrsMo ear eaadttcrt to eth raea fo PDP ourxepse vai teh ictona of hT1 tspyohcmeyl in apstniet suoiyrlpve odpesex to MBT. yTeh are the rdmanepoint clel tpey fuond at hte seit of DPP erxeusop e(th raae fo kins niteinocj at 48 ho,urs ewhn st'i rd)ae and salo ni teh gsnlu fo apisttne with muaynrlpo ueci.tuossbrl