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NBME 17 Answers

nbme17/Block 4/Question#33 (4.7 difficulty score)
An otherwise asymptomatic 52-year-old woman ...
Failure of the ovaries to secrete 17β-estradiol🔍

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submitted by cassdawg(548),

This is normal menopause (FA2020 p636). Average age of onset is 51 years (our woman is 52). Hot flashes are a common symptom.

In menopause, the ovaries stop secreting estrogen (17beta-estradiol is an estrogen) due to a decline in the number of ovarian follicles with age. FSH is increased because the feedback inhibition is removed. The source of estrogen after menopause becomes peripheral conversion of androgens.

peteandplop  FA2019 p622 +1  
cheesetouch  FA2018 P617 +