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NBME 16 Answers

nbme16/Block 4/Question#26 (5.2 difficulty score)
A 42-year-old woman undergoes biopsy of ...
High-grade, low-stage neoplasm🔍

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Grade refers to the differentiation, whereas stage refers to the TNM decriptions

This is high-grade because of the "poorly demarcated... cells growing in sheets" wit a high N:C ratio. Means it's got low differentiation.

This is low-stage because there is NO METASTASIS. Even though there is invasion (and thus, a cancer), M for the TNM is most important.

the_enigma28  Excellent explanation. For additional info, look up at Page 220, FA 2020. +