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NBME 16 Answers

nbme16/Block 2/Question#50 (9.1 difficulty score)
A 35-year-old man comes to the physician ...
Adenylyl cyclase🔍
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submitted by geekymle(7),

i tried but i'm not able to reason this question. can anyone please help me on this?

sunnyd  I found a good explanation in the discussion here: https://forums.studentdoctor.net/threads/nbme-16-help.1059939/page-2 +  
geekymle  thank you! it was the wording of the question which got me!! +1  
andro  I think there were two possible ways of approaching this. The first was by appreciating that the tumor cells ( which release Growth Hormone ) would express growth hormone releasing hormone receptors GHRH receptors - GHRH uses the Gs signalling pathway ( Net effect an increase in cAMP from the increased activity of adenyl cyclase ) The second and more straight forward approach From the stem of the question already they told us we are dealing with an overactivation of the G alpha stimulatory subunit . If the GTPase aint working ( meaning it cant be inactivated ) , the effect would be an increase in the activity of adenyl cyclase +3