-alol and -ilol (i.e. labetalol and carvadilol) are nonspecific blockers of alpha and beta receptors. (FA2020 p245)

• Hydralazine increases cGMP and causes smooth muscle relaxation via vasodilation. It is used in acute hypertension and is safe to use in pregnancy.
• Phenoxybenzamine is an irreversible nonspecific alpha blocker used pre-surgically in pheochromocytoma.
• Phentolamine is a reversible nonspecific alpha blocke given in some cases of severe acute hypertension such as for hypertensive crisis from MAOis.
• Trimethaphan is a blocker of the presynaptic nicotinic AcH receptors for both the sympathetic and parasympathetic nervous systems.