Vincristine is a common cause of chemotherapy-associated peripheral neuropathy (with cisplatin also having an association with neuropathy but not being used for breast cancer). Vincristine acts by binding tubulin and inhibiting microtubule polymerization. This affects cancer cells by inhibiting division, but also affects axons by inhibiting axonal transport.
submitted by โcassdawg(1781)
"Vincristine crisps the nerves" (FA2020 p441)
Vincristine is a common cause of chemotherapy-associated peripheral neuropathy (with cisplatin also having an association with neuropathy but not being used for breast cancer). Vincristine acts by binding tubulin and inhibiting microtubule polymerization. This affects cancer cells by inhibiting division, but also affects axons by inhibiting axonal transport.