Due to "contraction alkalosis"
loop diuretics cause volume contraction, thats why you give them.
As a result, there is increase angiotensin II release, increase in Na+/H+ exchange in the PCT (a function of increase angiotensin II), and then increased HCO3- reabsorption, leading to alkalosis
cassdawgImportant to remember: Loop and Thiazide diuretics cause alkalosis; Carbonic anhydrase inhibitors and potassium sparing diuretics cause acidosis (FA2020 p609)+9
submitted by โergogenic22(401)
Due to "contraction alkalosis" loop diuretics cause volume contraction, thats why you give them.
As a result, there is increase angiotensin II release, increase in Na+/H+ exchange in the PCT (a function of increase angiotensin II), and then increased HCO3- reabsorption, leading to alkalosis