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Retired NBME 15 Answers

nbme15/Block 2/Question#20 (reveal difficulty score)
A 30-year-old man is brought to the physician ...
Porphobilinogen deaminase ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—cassdawg(1781)
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This man has acute intermittent porphyria which is a deficiency in porphobilinogen deaminase because: (FA2020 p425)

  • Painful abdomen
  • Port-wine colored urine (burgundy urine)
  • Precipitated by drugs - triggered by TMP/SMX
  • Psychological disturbances - irrational behavior
  • Family history
  • Increased 5-ALA and porphobilinogen which are the two prior substances in the heme synthesis pathway that would be backed up
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cheesetouch  fa18 p 413 +1



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