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NBME 15 Answers

nbme15/Block 1/Question#24 (10.7 difficulty score)
A 3-year-old girl is brought to the physician ...
Interferon-gamma receptorπŸ”

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submitted by andro(173),

Note: IL-12 receptor deficiency, or a defect in the Interferon Gamma receptor
Think Disseminated Mycobacterial and Fungal Infections . Also salmonella *

cassdawg  Disseminated mycobacterial infections occur more often with interferon gamma receptor or IL-12 receptor deficiencies due to impaired ability to form granulomas (IL-12 and IFNgamma are the main cytokines involved in granuloma formation). +2  
cheesetouch  FA2018 P 116 under il-12 receptor deficiency +1  
cheesetouch  Also on FA18 p 102 related to Th1 response +