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Retired NBME 15 Answers

nbme15/Block 0/Question#0 (reveal difficulty score)
A 1-month old male newborn is brought to the ...
Number of Melanocytes = Normal, Melanosomes = โ†“ ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: biochem repeat

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submitted by โˆ—cassdawg(1781)
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This is a case of albinism, most likely due to decreased tyrosinase activity or decreased tyrosine transport (both are required in synthesis of melanin). Thus, there is a normal number of melanocytes and a decreased amount of melanin.

Vitilligo (characterized by irregular hypopigmented patches) is caused by destruction of melanocytes and thus would have decreased melanocytes.

FA2020 p476

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