NBME Answers ↦
joonam
Hey bro, thank you so much for your contributions on these free 120 questions. Your advice on test taking strategies for step 1 have been very helpful.
+21
2019-07-07T21:28:53Z
luciana
"Elaborated enzymes by H. pylori may also contribute directly to epithelial cell injury. Ammonia produced through urease activity may be toxic to gastric epithelial cells. H. pylori protease and lipase degrade gastric mucus and disrupt the phospholipid-rich layer at the apical epithelial cell surface, allowing for cell injury from back diffusion of gastric acid."
https://www.ncbi.nlm.nih.gov/pubmed/9394757
+2
2020-01-16T21:33:01Z
luciana
I got tricked :( Thought the damage was due to destruction of local somatostatin cells with increased gastrin and acid production... but this is actually the mechanism of duodenal ulcers development related to H. pylori
But makes sense, so thats how the somatostatin producing cells are destroyed lol
+4
2020-01-16T21:38:07Z
drpee
"Hyperacidity and gastric ulcer development" is also sort of true, but this is hinting at the mechanism for DUODENAL ulcer development from H Pylori. Irritation in the stomach leads to G Cell hyperplasia, increasing acid secrection which causes downstream ulceration.
+5
2020-03-27T23:03:05Z
itsalwayslupus
Did anyone else pick the hyperacidity answer just because the correct answer had "local tissue destruction" in it? I figured that H. Pylori was non-invasive, so would not directly damage the tissue it is localized too
+4
2020-05-05T15:54:41Z
cbreland
@itsalwayslupus exact same thoughts over here
+
2020-06-13T19:24:01Z
em_goldman
H pylori is sometimes described as helical but more often as curved, but is (confusingly) not a spirochete. Spirochete refers to a particular family, Spirochaete, and are markedly corkscrew. The three important spirochete bugs for Step 1 are Leptospira, Borrelia spp., and Treponema pallidum; Brachyspira spp. get an honorable mention but idk they're high yield for Step 1. Anything other kind of bug is not going to be a spirochete. Additionally, H. pylori is not invasive, and instead resides on the surface of the gastric mucosa. The picture showed some bacteria inside the lumen of glands, not intracellulary.
+6
2020-01-09T23:27:53Z
em_goldman
*idk if they're high yield
+
2020-01-09T23:28:15Z
em_goldman
*any other kind of bug gosh dang it, lol, definitely in dedicated rn
+
2020-01-09T23:28:59Z
dang90
I also think spirochetes dont "invade" either. They colonize in the gastrum antrum releasing urease to thrive but don't invade.
+
2020-07-02T17:44:28Z
submitted by benwhite_dotcom(469), 2019-06-26T22:17:24Z
As a,lyswa itsβ olmats rtebte ot inreog het eriupstc wneh l.sbospei Thsi nagemtnel has a piecpt ru,elc hwich ew wkon si uscade donpelmaieytr by .H yrpiol cion.etnfi .H rlpioy deucrsop toeserspa and uiallcarrtpy seu,rea icwhh woall ti to neresaci het pH of tsi colla nitvmnonree yb vignaecl eura toin ,maoanmi hhciw si cxoit to sraigct so.macu The urtpcei snmdtetseora H yl,oirp wchhi era idtenve twih vrslei ingtia.ns