This is serum sickness, a type III (immune complex) hypersensitivity.
the gave the pt. a protein that is not from human body (it was a rabbit protein) that should clue you into serum sickness. this reaction happens after chimeric antibodies for cancer medications too. serum sickness usually takes 5days to 3 weeks to happen after the infusion. just remember, protein that is not from you can be antigenic to your body. serum sickness is type III hypersensitivity hence the answer.
FA 2020 pg 421
clue: anthithymocyte is immnosuppressive regimen for aplastic anemia. The patient has bone marrow failure.
Even we don't know the fact, we can match Immunosuppressive = Immune complex deposition in tissues.
FA 2020 pg 421
clue: anthithymocyte is immnosuppressive regimen for aplastic anemia. The patient has bone marrow failure.
Even we don't know the fact, we can match Immunosuppressive = Immune complex deposition in tissues.
submitted by โhungrybox(1277)
This whole question is on the different types of hypersensitivity. (pg. 113 FA2019)
eosinophil degranulation โ Type 1 hypersensitivity (mast cells early, eosinophils/others later)
widespread apoptosis of B lymphocytes โ B lymphocytes are involved in Type 2 hypersensitivity. Widespread apoptosis would not occur. If anything, B cells would proliferate?
Cytokine secretion by natural killer cells โ NK cells use perforin and granzymes to induce apoptosis in type 2 hypersensitivity. (Not sure if they secrete any relevant cytokines...)
immune complex deposition in tissues โ serum sickness (Type 3 hypersensitivity)
polyclonal T-lymphocyte activation โ type 4 hypersensitivity