Carbamazepine is a notorious CYP450 inducer, so you should be guessing metabolism no matter what. CYP450 plays an important role in both vitamin D bioactivation and degradation in the liver.
mambaforstepahhhh i didnt know CYP450 played a role in vit D bioactivation/degradation. thanks!+8
mariameJust to add:
Vitamin D signal transduction system involves a series of cytochrome P450-containing sterol hydroxylases to generate and degrade the active hormone, 1ฮฑ,25-dihydroxyvitamin D3.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927478/+1
I get the P450 point, got it wrong bc anti-epileptic drugs such as carbamazepine and phenytoin decreases folate absorption, but maybe it is a different mechanism with vitamin D
submitted by โbwdc(697)
Carbamazepine is a notorious CYP450 inducer, so you should be guessing metabolism no matter what. CYP450 plays an important role in both vitamin D bioactivation and degradation in the liver.