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Retired NBME 21 Answers

nbme21/Block 4/Question#4 (reveal difficulty score)
The FOXO transcription factor responds to ...
Nuclear/cytoplasmic shuttling: yes;
Serine phosphorylation: yes
Ubiquitin-mediated proteolysis: no ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: biochem

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 +13  upvote downvote
submitted by calcium196(12)
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tU-bdtniidqmieuaie ooestpsliry si nto rleseybvri fecdefta yb inls.uin The ontiesuq asks rof ilbvesrree asyw hatt iinlsun efafsct ,it nad niaubttioiiuqn wdolu elad ot oertandagid aiv pstesa,eor hhcwi is ton lreeb.eisvr s/ralatcNioccmelpyu giusthnn aksme ssene ebuscae OFOX si a rtincaotpsrin art,ofc os it tacnโ€™ do its jbo if it is ni het myosa!tcpl

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meningitis  khaTn uyo rof yoru aaepnxotni!l Oe n nsuiqo:et How buaot eth nserei oprhyl?oanspoiht Is ti wdnreeas by epru toiznemormai thta het OOFX TF si eiesrn poode,rpaytslhh ro si ti a eeanlrg tcaf atth lal Ts'F rae ornrent-sieheine atryophdspole?h +
tsl19  I'm tno seru, btu it yma eb as iempsl as ts:hi -nutadiqibedtuiime ritlyoespso is srvrei,rieelb ubt obth /CN uglsnthti nad ynhrlohpiopotsa ear neellygra rlveeirsbe pcrss.eoes +
didelphus  I sola egussed htta OXOF utms be a tpar fo eth IP3K atyhwa,p inces snuilin egtuelsra itmlemaosb urgthoh KI3P dan teh unqtiose etsm lscficiyapel mnitesno thta. Pyirntohpsalhoo is a amorj rpat of htta tyaw,pah so neve rceyinidtl thropyialosponh uoldw graeuetl O.XFO rgauittnFsr os.tnqeui +21
niboonsh  yse, XOFO si cdeatffe tsrdewnoma of het vtoanticai of KIP.3 ihTs si a rllaey dgoo eovid thta pexnsali hte ehwol seaccda y/g:ww9u.t.?w4s-3hNa/oepwhwsmtbdeutcvL=oct/ +2
alexb  crdnigocA to daiwieikp (p:ist//.kpF1ieowh/gieOtridn.Oki/waX) npihoypootlshra fo XFOO1 is belrrviir.ees iTsh si rreiferng to oplastiorhoynph of rseeni iseduser on OXOF by k,tA hwhic usrcco ni ssroeenp ot iniu.lns tBu het EMBN rweasn ggesstsu ti's i.rbveeelsr h'atWs p?u +2
almondbreeze  lcdou kwii eb gnwro no ptloapynsroiohh nibeg relbeivr?sier craidongc ot htsi iecalt,r ti is a lvsebreeri oecssr:p tuaoglnier of oFxO ptsrcnitoairn rasfcot by lrbeeivers altshrpophooiyn nad lenttcaaioy (wi4r0ipt#ec1cei3e9871d/./te/t.osw0sc0ss6eiacmt0S/e0plr17/i10ch8cwn0/n5ic:m) eso iiwk nfo,i e,owrhev si lhlepfu : In its eld-prspyaouthohn t,aste 1OFXO is izdllaoce to the uu,elscn ewrhe it sbind to eth nniusil peoersns quecesne eoaldct in hte ropertom fro eclguso seshtph-p6oaa nda caeessirn its ater of irnrtipoans.tc ,FO1OX ohurthg encisanirg scnirotipnatr of p-g6phslase,-ueooatchs rnidlteicy ecnesiars eth etra of apcehti goucles io].nu1crd9pt[o oHeverw, hwne OXOF1 si thdopyoahrepls by tkA no 4h2T,r- 6r5,-Se2 and -,3S9r1e it is dcudxele fomr eth suulc,en erweh it is tenh edbutuintiiaq dna addegerd. ehT hnytaiorlohopsp fo FXO1O yb Atk usenlqbestuy essedcera eht paectih oelsgcu onriupctod rhutogh a eeaerscd ni onisairrtctnp fo egslocu e.a6pts-ahspoh +
leaf_house  It esmse keil eth hytlpooanrisohp ofrm kAt sdale ot duicstrn,teo tbu abmey het taopsmiusn si htta atth yoilhatorspnohp tesp (iuxednlcg verye retho pets fo oeionmiorsuuetpq-tbi ypatah)w si erevr,bslie erehw yrotpslosie si la.ifn i onobsn@h idoev si godo but s'edotn plsit htis ne.o +


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 +11  upvote downvote
submitted by โˆ—imgdoc(183)
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This oueinqts si snagik utaob het ininslu roeectpr isynoert nikeas .tawhayp oS atek ti fmor r,eeht

  1. eTh roholotpypainhs of teh IRS avcsieatt a gnslai nristdutncoa edacasc ahtt elsda ot eht tiaoantvci fo hoetr naesksi as lewl sa spinrirttnaco csroatf thta metaedi the lrtlancelirau fcfeset fo .ulisnni yCmisNaueotlacrclp/ ugsitlhtn - yes bvresil)ee(r

  2. rSoeTerien/einhn aniesks are olas wnokn ot derceu eht tvyaicti fo unls.ini - sey svri)eerb(le

  3. ituUiqbni - iaddemet ooertlissyp - on otn( erre)i,veslb nda aols inslnui metlyaallbcoi nsrcsaiee ntioper hystsnesi so it 'dnoets ctahm tahw liuinsn edos y.nsyaaw

trrocec em fi m'I .ngrwo

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usmle11a  i hkint yuoer etcorcr uscea iuubinqti amiddtee tlyooepris is na riersileebvr tpe.s +1


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 +7  upvote downvote
submitted by โˆ—hello(429)
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heT Q emst seastt OXFO si a nrtaciirsonpt rotfac taht erdnposs to iisnuln nlsiaiggn yb alrtinge hte ospartinrcitn of abomeclit esnge -g&t;- te,rreofhe FOXO si a patrnsoncitri ortcaf vlvodien in asmiolte.bm hTis ohldus mkae nsese buaseec ntcieeoulrisrnp- tainivtaoc has a lreo in unegarltig immeolsba.t

Tish Q asks btauo elrbvresei aswy hatt iluisnn etesrgua OOFX tnpasrocrnti forcat ivc.aiytt

iiqtmaidubete-dUni lsotiyorpes si erelvrriebsi. iiltmEnae all ohcesci pteecx for ,B D, adn .H

rtnlnerisI-euocsp inutofnc hghtruo IPK3 gg.isinnla I3KP aiisggnnl nlvsioev pyhooapsitrnlho of ieresn -&;-gt eenisr pshnophoaitoyrl is a srbeeiverl sesc.orp lientmaEi .H :FIY /eonotmpairni idac phoinylshtporoa is awlysa elirbersve.

uoY ear tlef whit cciesho B nad .D

XOFO si a rtcitaonrisnp foactr ;g--&t itnarposcrtni osrafct ieetadm geen yaivittc by ntsthlgui neebwet het yaompsctl and lce.nsuu uatggiRlne het olitnoca fo OOFX cnrirtsptnioa tcaorf ie(.. msycoaptl s.v c)elunus lliw etrhoeefr vslreiyrbe aeuodmlt Xta-OedOmediF aiemcbolt enge avci.tyti

Tihs velesa uoy hwit hte eoctcrr :seanwr Cehioc .B

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adong  A eebttr ayw ot htnki atbou ti is nlisuin sact uhohgtr PMAK cwihh si a enoisnitnreeerh/ nksaie +1
amy  I rieadnpttete ci/seopytmracalCNlu tlusgihnt lwuod eb the elustr fo sieren oihoylasppnor,th os eht irsevreebl fncitoaidmoi is lyon no rieens srtlphioynoapoh, wichh alde ot eslccaomcupnry/atli ,gltsniuth utb hte tunhlgtis tslfie is not unerd tdI moiiocifan. got it ow.grn +


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 +1  upvote downvote
submitted by โˆ—usmleuser007(464)
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nrSiee hiohorplyasnpto ilwl edcuer siinunsl' sca.efft tI scta no eth tniyreso iesk.an

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alexandramda  /cn(wfte/spil-h9rmp8/t0.t-:390fwoc)8d0r-7leco02/.020g9wSdoub./l6py +


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