NBME 21 Nuclear/cytoplasmic shuttling: yes;<br />Serine phosphorylation: yes<br />Ubiquitin-mediated proteolysis: no (NBME Answers)

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Retired NBME 21 Answers

nbme21/Block 4/Question#4 (reveal difficulty score)
The FOXO transcription factor responds to ...
Nuclear/cytoplasmic shuttling: yes;
Serine phosphorylation: yes
Ubiquitin-mediated proteolysis: no 🔍 / 📺 / 🌳 / 📖
tags: biochem

+13 upvote downvote
submitted by calcium196(12)

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tetiieaUq-idinbmud ysporoitsel is nto eivsbyrler eftaefdc yb siin.unl heT oistnque sksa for lrebvieers yswa htat suilnni cetfsfa i,t dan butotunqniiiai oldwu dlea to idrgtnadeoa avi por,sstaee hcwih is ont eribs.verel scuitr/Nypclaleocma tuignnsh eskma enses aubeces OFOX si a otnisrctirpna rtafc,o so ti t’cna od tis job fi it si ni the tsa!mopycl

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meningitis Tankh uoy orf oryu !enpoltanxia e nO n:qouseit owH oatub hte enirse pyhh?ironpooslat Is it erdneaws yb rpue omnoieatzrim ahtt teh OOFX TF is rsiene ,roypphoadlsteh or si it a gnerela caft that lal TsF' aer tnees-nernroeiih oy?rlshaepthpdo +

tsl19 mI' tno ser,u tbu it amy be sa pimels as i:tsh naiqieudii-btetudm iserpooytls si rirb,seleeirv btu htob NC/ thilgstnu nad nroohyaipplhsot aer eaynlerlg beeiveslrr sspeso.ecr +

didelphus I lsoa sdgesue atht OOFX stum eb a trpa of eht 3IPK pwaaty,h esinc uilisnn stlereuag leastmibmo rtghuho PI3K dan eth sitnoque tmse iycclfsilpea mnneoits tht.a lyhnpaotoihPors si a ajrmo atrp fo tath tpyawha, so enve ydtclinrie lhotranshipoopy wolud geluaert O.FXO Fsrnttiruag .iqoteuns +21

niboonsh sye, OFXO si dfaeftec eomdrwnats fo hte ioicnatvta of PI.3K iThs si a lleray oodg doeiv ttah xeisplna eht olhwe aescdac ts.:wLv/=ohoNuwwhem?y-3/9w/ad4ctbuttcswe.pg +2

alexb dicnArgco to pkieiaidw (/i/1/p.iiegiiOtwsF.ekX/tw:odphOnakr) sploinhyorphato of XFOO1 si irrsvbie.eelr hsTi is nfriregre to olyooprstnaihhp of eeirns seiserdu on XOOF yb ,Akt ihchw crucso in seorsnep ot nuln.sii But hte EBMN wasren eusgsgst t'is rv.beeliesr hasWt' u?p +2

almondbreeze oucld kiwi be onrgw no hpilrtoonhpyoas nbegi iver?srrebeil nccodargi to hist alecr,it it si a vlbseireer so:repcs tgnaoriule of oFxO rinpicarnsott stcrfao by ersrbeevli hypiloontraposh nad ioetltaycan (cl6/00pc8/ia0hi/w40/7S93s/toc8weewncitneepsc1e1rsdtrmt:05e0i0#/cisi.c.171sem) o wiik ,foin ,eoehwrv is puhellf : nI sti tpdyaeurnshoploh- att,es O1XFO si dlciaolez ot the ,luseucn ewerh it bdisn to het lsnuini sepnesor euenecqs cdteaol ni eth teropmor rof lesogcu ppsos-athh6ea adn nseiarces its reta of iatptcns.ironr F1OO,X uhohgtr ingrsecain iaitcsrnnpotr fo sl-s6atuep,ea-cphshgoo lcrediynit cnsisaere eth tera of ephciat slogeuc cod1tuon[.]ri9p woe,rHev enwh 1OXFO si apodtlsyhehpor yb Akt on 4Thr2-, 25,-r6Se and 91,-r3Se ti si deludxce fmro eht us,lecun erhwe it is hten nbiatuqidtiue nad g.daddeer hTe ayooptosphhnril fo OFX1O yb tAk uyesqsutnlbe esrecedsa the hceitap cseoulg ntdcprouio ugtohhr a rcadseee in rsniactotrinp of lucgseo atp6oshe-.ashp +

leaf_house It sseem ikel eth tprlhshooioyanp rfom ktA ldase to oc,situerntd but yambe teh sipsntoaum si tath that htspyhapnoriloo setp cdg(leixun yvree rthoe sept fo npio-orouesbitmeiqtu atpayhw) si ,vlsbererei werhe soseioyprtl si lifa.n noh o@nsib evdoi si gdoo btu ned'ost lpsti tshi n.oe +

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submitted by ∗imgdoc(183)

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Tihs tnqsoeui is knasgi utaob het uliisnn creoprte tinreyso naeisk yw.apaht So ktae ti rmof ehte,r

heT olnyhapropthiso fo eht SRI aattvesci a lngias ndancrotsuti adaecsc ttha dalse to het tivotaainc fo erhto einsask as llwe as noptriacsnrit rfoatcs thta meaeidt teh iuellanralrtc etseffc fo uii.nlsn Nioll/cayrtacsmueCp nhgitsltu - eys ()errielvesb
neier/inSroTeneh nisseak era loas nkwon ot cerdue teh yittiavc fo nsiinul. - yes rrbe(il)svee
utqnUiiib - dteiaemd opysilrstoe - no (tno ei,esvbr)erl nda saol uninsil bilcaeyoltlam eeacrnsis rpoiten iehtssyns so it t'noesd cahmt awth ulinisn esod wnsyay.a

ctercor me fi I'm r.onwg

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usmle11a i hkint ueory octrcer scuea bqtuiiinu didtamee oorlepyist si na rseribielrev pts.e +1

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+7 upvote downvote
submitted by ∗hello(429)

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The Q mest esatst OXFO si a iitsnatropcrn rtafco that nepdross ot nniisul algigsnin by lietrnag het crtiorpannits of cibmolate egnse ;-g-t& ,rotfreeeh XOFO is a aticsprnntoir octafr vonledvi ni mmosaebt.li hsTi lhudso ekma esens cbeueas rctilsinupe-enor oainatcvti sha a leor in ilagtnrgeu amsemblt.io

sTih Q sska touab lrireseevb ayws ahtt nnsiiul sgaeuert OOXF otrnsairtcnp fcaotr atitv.yic

dietbdii-nmaqiUtue olyiosertsp is vieelrrbisre. mietEilna all ohccies eeptcx orf ,B ,D and .H

osrnrise-epctunlI fntinuco horught I3KP g.aiiglsnn KI3P iigslnagn nloisevv taohyoorhppslin of enirse &-t;-g erenis plpsoohnaroytih is a ersrevlbei o.scpres aiiltmEne .H Y:FI ntiopiaonmr/e daci ihorosppthaynol si waayls esirev.brel

ouY aer eltf whit iccseho B adn D.

FOXO is a npsorrntiicta rafcto -g-&;t rroncpiaitnst crtaofs mtaedie ngee iitvycat by hglnsutit bteeenw eht tacmlysop adn lncues.u eaRlnggtui eth naloitco of OXFO oipnrnaistrct ctaorf ..ie( yclpoatsm vs. unlsu)ec wlil htrfeeroe vleersriby etualomd ad-FOXOedetim tceolbima gene i.atyicvt

siTh evasle uoy hitw eht cecrrto nes:war eCciho .B

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adong A eebrtt yaw ot thikn utoba it si usliinn scta hugtroh KMAP hwhic si a ehieeisnrrntn/eo isaken +1

amy I ttenierdtape tprlaN/caclsomCeyui nshtiglut owudl be hte resltu fo eirens lpoinhtyoosphr,a os teh eribevresl dofcniomiati si lyon no risene sohpaoirl,ophtyn wchhi eadl ot uytomelacrlpnci/csa uns,htiglt tbu hte uitstnlhg sftlie is tno unred oitImoidcfan .i otg it gw.nro +

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+1 upvote downvote
submitted by ∗usmleuser007(464)

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rineSe phtyipaonlohsor iwll eeurcd nsl'isiun ta.fcsfe tI ctas no hte yoestrin aks.ine

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alexandramda thf20Sp/-0w/po9e-.mo0d(lr0ti0.d8/w:-nw97gctr.3l/)c0flseb/u29p6yc8o +

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