NBME Answers : nowherekid139's page

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I put constipation because I thought the medication being described might be CCB: can someone explain why nitrates over CCB?

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seracen Wouldn't nitrates be a faster acting drug here? That was my take-away anyway. One is more acute, the other for long term maintenance. +4

suckitnbme I also believe it's because CCBs have minimal effect on venous beds and would not cause a significant decrease on preload. +3

beto decrease of cardiac preload is another word of Venodilation, so Nitrates primarly venodilators. CCB dilate arteria more than veins +1

zevvyt also, verapamil is the one that causes constipation. But Verampamil is non-dyhydropiridine, so it works more on the heart than the vessels +3

nowherekid139 CCB- decrease afterload by vasodilating arteries by acting on smooth muscle (remember arteries are muscular, veins are flimsy) Nitrates- decrease preload by vasodilating veins Hope that helps! +