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Just adding support to the above explanation:
do all azoles or just itraconazole only requires an acidic environment to be absorbed?
@chandlerbas, where did you find this information? I was looking over this on FA but they do not mention it and I would like a bit more information. Thanks!
haha no stress! the article above submitted by @necrotizingfasciitis does a descent job explaining it, however its not good enough, I looked into a bit more on uptodate but wasn't fruitful in my endeavours. goodluck!
How are we supposed to know this!! It is not in UWORLD or FA right?
Someone said it on here, since there was no CYP inducer of the answer choices, the only way to even think about an answer to this question was to just go with a less acidic environment from the PPI affecting absorption. It was simply the only reasonable answer choice, I don't think there's any way we were expected to know of this exact interaction prior
Golan pharm book states the exact same thing. Cannot be given to patients with acholrhydria.