NBME 24 Secreted by the proximal tubule (NBME Answers)

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A 40-year-old woman with a 25-year history of ...
Secreted by the proximal tubule 🔍 / 📺 / 🌳 / 📖
tags: renal

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submitted by ∗xxabi(293)

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Creatinine clearance slightly overestimates GFR because creatinine is moderately secreted by PCT

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ih8payingfordis On that same vein, it's important to note that para-hippuric acid (PAH) is used to estimate effective renal plasma flow (eRPF). In this case, ePRF UNDERestimate the real deal not all ingested PAH is excreted. (FA 2019 pg 507) Creatinine OVERestimates GFR PAH UNDERestimate RPF +3

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submitted by ∗usmleuser007(464)

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Most absorption ad secretion is done at the PCT. It is this reason why the PCT is the most metabolically active portion of the nephron.

As this image shows, you can see that reabsorption & secretion occurs at the PCT

this means that both PAH & creatinine are secreted for elimination at the PCT along with the additional volume freely filtered through the bowman's capsule.

Furthermore; Inulin is neither secreted nor reabsorbed.

hence Inulin is better for GFR. But, creatinine is normally used for GFR as an estimate (probably d/t ease)

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