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vshummy
Synaptobrevin is a SNARE protein. Why they couldnโt just give us SNARE Iโll never know.
+52
yotsubato
Cause they're dicks, and they watched sketchy to make sure our buzzwords were removed from the exam
+53
yotsubato
Oh and they read FA and did UW to make sure its not in there either
+42
soph
This toxin binds to the presynaptic membrane of the neuromuscular junction and is internalized and transported retroaxonally to the spinal cord. Enzymatically, tetanus toxin is a zinc metalloprotease that cleaves the protein synaptobrevin, an integral neurovesicle protein involved in membrane fusion. Without membrane fusion, the release of inhibitory neurotransmitters glycine and GABA is blocked. -rx questions!
+6
qfever
So out of curiosity I checked out B) N-Acetylneuraminic acid
It's sialic acid
typical NBME
+2
alexxxx30
shocked they haven't started calling a "farmworker" a "drudge" <-- word I pulled from thesaurus.
+3
snripper
"You shouldn't memorize buzzwords. You gotta learn how to think."
Lemme pick another random ass word that doesn't have anything to do with critical thinking skills and use it instead.
+10
mw126
Just as an FYI, there are multiple "SNARE" Proteins. Syntaxin, SNAP 25, Synaptobrevin (VAMP). From google it looks like Tetanospasmin cleaves Synaptobrevin (VAMP). Botulism toxin has multiple serotypes that target any of the SNARE proteins.
+2
wrongcareer69
Here's one fact I won't forget: Step 1 testwriters are incels
+4
j44n
its not an ACH-E inhib because he doesnt have dumbell signs
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ooooopss
Buzzwords often carry us to the promised land im dyingggg. It's 9pm and I'm cracking up LOL
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srmtn
this is someway confusing, because BOTH toxins are proteases that cleave SNARE proteins (that allows release of neurotransmitters), the difference is that tetani prevents release of GABA and Glysine (inhibitory) and botulinum prevents release of Ach (stimulatory)
+1
utap2001
Tetanus toxin which proteolysis synaptobrevin thereby inhibiting secretion of vesicles from neurons. GABA and glycine are therefore inhibited.
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submitted by โlsmarshall(465)
Synaptobrevin is the target of tetanospasmin (tetanus toxin); muscle spasms are characteristic. Only other answer you might consider is Acetylcholinesterase since he is a farmer and buzzwords often carry us to the promised land... but symptoms of a cholinergic storm are absent.