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NBME 24 Answers

nbme24/Block 2/Question#39 (18.1 difficulty score)
A 3-year-old boy has short stature and ...
Endochondral ossificationπŸ”

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submitted by m-ice(326),
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iThs boy hsa hpdanrcaoiso,la ihchw is edascu yb an asmlauoto ntdmaion amtinout ni isFlarbobt trowhG ocratF preeotRc 3. FGF ngiiagsln is eenedd fro rprepo egiracatl t,nnoufci nda iuothtw ti, eht gonl senbo fo eth yobd illw tno gwor cubesea eth ogtwhr eaplt (dmae of hctesnroody)c edso not fniu.ontc oevHwe,r obens that nuegrod nebumrosam ctiaoi,osfnsi leik the ebsno of teh ,ehad ilwl rowg lmny.oral siTh rtssule in eth ptetina ihgavn storh itxesetremi htwi a lmanor iezs krnut nad eragl head vrtilaee to het ibs.lm

mumenrider4ever  Small edit, achondroplasia is due to constitutive activation (not inactivation) of FGFR3, which inhibits chondrocyte proliferation +8  

submitted by madojo(163),
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The waerns si not estlocstoa aitvcyit aceseub thta wudlo be nererfirg to oirosetoespts ni hhciw reteh is a tedcfe ni ocotslaste aittvciy nda oyu ahve ihckt desne neobs htta carrutfe aeisyl. operrImp ltoastsceo yvattici ldcou saol eefrr ot sPtega sedasei of het ebon kaa tseiOist mfnredaso tbu I ndt'o ithkn ttha oudlw eeptnsr tsih onygu dan douwl eb rome castsidoea ihtw oenb geomierdln esombprl nda an eiarnsec ni aht ize,s tec.

hTe hdea iezs i'nts drcesaien it sjut soklo kiel a raelg eahd ni noascpirmo ot the srdwiafm eeusbac iaodarphasclno tdsno'e fceaft raumsonmeb nosbe of hte .deah rIdnescea ghtwro onomerh stnhsyeis wudol eb aoalcyremg I itnkh ubt atth si eesn in .aldtus oLw asnal dbiegr = sdldae seon.

TIM btu ni AF esthre' gmhitnoes eladcl nraLo yremndso cihhw si A,R dna a eedcvtife HG corteepr so yuo veah cesnredai GH adn wludo olas see sdrwiamf adn a lddsae neso adn oipentrnm fdroeeha utb a lslma edah