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NBME 24 Answers

nbme24/Block 2/Question#9

In which of the following stages of the cell cycle ...


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submitted by sweetmed(83),

Cyclin A,D,E and for G1 to S transition [made in G1]. Cyclin B is for G2 to M transition[made in G2].

mousie  http://www.sparknotes.com/biology/cellreproduction/cellcycle/section3/page/2/ +3  
fahmed14  Cyclins help regulate cell cycle phases. They help with checkpoints before progression to the next phase of a cell cycle. Therefore the checkpoint before mitosis would be in G2 and probably where mitotic specific cyclins are synthesized +6  
artist90  https://en.wikipedia.org/wiki/Cyclin . 4 types of Cyclins and when they rise and fall. +1  

 +5  upvote downvote
submitted by madojo(49),

Another way to think about this is whats the closes stage to mitosis because right before M (mitosis) you need to have mitotic cyclins synthesized, and that would be G2

G1 --> S --> G2 --> M

G1 checkpoint: Cyclin D/CDK4 complex with p53 and rb G2 checkpoint: Cyclin B and CDK 1

Way to remember: G1 is associated with higher numbers D and 4 G2 is associated with B and 1


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