NBME 24 Answers ↦
she is also volume overloaded. more fluid leads to a decrease in Hematocrit.
I thought PTH increases 1-alpha-hydroxylase which increases levels of 1 ,25?
it's supposed to in the setting of proper kidney fxn
The decrease in GFR leads to decreased delivery of 25 dihydro vit D to the PCT and the decrease in functional renal mass limits production of 1a-hydroxylase. The increase in PO4 also stimulates FGF-23 from bone, which inhibits PO4 reabsorption and 1a-hydroxylase.