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Retired NBME 24 Answers

nbme24/Block 1/Question#12 (reveal difficulty score)
A 26-year-old man comes to the physician for ...
Increased number of LDL receptors on hepatocytes ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: pharm cardio

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 +9  upvote downvote
submitted by โˆ—m-ice(370)
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HMG CoA reductase inhibitors block the ability of the body to produce its own cholesterol. The liver, unable to make its own cholesterol and still needing to do its job of making lipoproteins, needs to get it from somewhere. So, the liver increases expression of LDL receptors to take more LDL out of the blood for repackaging.

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an_improved_me  just a quick addition: LDL is the main lipoprotein carrying cholesterl, hence the liver's selective increase in LDL receptors +2



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submitted by โˆ—peteralamir(3)
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Why did they ask this same questions twice doe

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submitted by โˆ—madamestep(17)
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All anticholesterol agents will upregulate the LDLR one way or another.

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submitted by โˆ—avicenna(12)
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Statins, also known as HMG-CoA reductase inhibitors don't forget this doctors should be able to explain such simple concepts like the back of their hand if a patient tries to act smart asking how this drug helps me lose cholesterol.

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